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The Effect of LMWH on ICSI in Patients With Unexplained Infertility and Negative Immunological Markers

Unexplained Infertility Clinical Trial

Official title:
The Effect of LMWH on ICSI Outcome in Patients With Unexplained Infertility and Negative Immunological Markers; a Randomized Controlled Trial

Clinical Trial Summary

The purpose of this study is to assess the efficacy of LMWH treatment in women with unexplained infertility and negative immunological markers undergoing ICSI.

Clinical Trial Description

Inclusion criteria:

1. patients undergoing 1st trial ICSI

2. unexplained infertility

3. negative immunological markers including ACL abs, LAC, ANA, ATA, AnitdsDNA

Exclusion criteria:

1. previous IVF/ICSI

2. Any cause of infertility

3. Suspected and/or unexpected poor response during ovulation induction

4. positive immunological markers

5. Age > 40 years.

All participants will undergo IVF/ICSI cycle using the Long luteal phase protocol. the dose of gonadotropins will be calculated according to patient age and BMI. All patients will have 2-3 embryos transferred at D5 according to their age. the primary outcome will be LBR. secondary outcomes will include biochemical pregnancy rate and clinical pregnancy rate. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02861105
Study type Interventional
Source Ain Shams University
Contact
Status Completed
Phase Phase 4
Start date January 2015
Completion date March 2016
View Details
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