Uncomplicated Malaria Clinical Trial
This will be an open-label trial in Burkina Faso assessing the pharmacokinetics of the antimalarial combination of dihydroartemisinin/piperaquine (DP, Duocotexcin) in children. Dihydroartemisinin-piperaquine is a promising candidate for first-line therapy of malaria. We hypothesize that the disposition and pharmacokinetics of DP will be altered in children, and this will alter the efficacy and/or toxicity of DP. We will test this hypothesis in this open-label trial in Burkina Faso. The target population includes residents, aged 6 months to 10 years in Bobo-Dioulasso. Children who present to the study clinics with symptoms suggestive of malaria will be screened with a thick blood smear. Subjects who meet selection criteria of treatment efficacy will be treated and followed up for 42 days. Pharmacokinetic sampling for DP will occur on selected follow-up days.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT00540202 -
Effectiveness of Oral Quinine and Artemether-Lumefantrine in the Treatment of Uncomplicated Malaria in Ugandan Children
|
Phase 4 | |
| Completed |
NCT02787070 -
A Randomized Controlled Trial on Malaria Primaquine Treatment in Timika, Indonesia (TRIPI)
|
Phase 4 | |
| Completed |
NCT01213433 -
Amodiaquine+Artesunate for Uncomplicated Malaria Treatment
|
Phase 4 | |
| Active, not recruiting |
NCT00406146 -
Amodiaquine+Artesunate vs. Artemether-Lumefantrine for Uncomplicated Malaria in Ghanaian Children
|
Phase 3 | |
| Completed |
NCT05192265 -
Efficacy and Safety of Pyronaridine-Artesunate Versus Artemether-Lumefantrine
|
Phase 2/Phase 3 | |
| Completed |
NCT04767191 -
Malaria Therapeutic Efficacy Study (TES) Kenya
|
Phase 4 | |
| Completed |
NCT04767217 -
Malaria Therapeutic Efficacy Study, Rwanda
|
Phase 4 | |
| Completed |
NCT06036030 -
Combination Momordica Charantia Extract and Primaquine Againts Plasmodium Falciparum Uncomplicated and Plasmodium Vivax Uncomplicated Treatment in Manokwari, West Papua
|
Phase 2 | |
| Recruiting |
NCT06064591 -
Host Immune and Metabolic Determinants of Sexual Conversion in Plasmodium Parasites IMMETASEX
|
||
| Completed |
NCT06300970 -
Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for Treatment of Plasmodium Falciparum Malaria in Liberia
|
Phase 4 | |
| Not yet recruiting |
NCT05911828 -
A Study to Determine Safety, Tolerability, and Pharmacokinetics of Different Orally Administered Regimens of the Combination ZY19489-Ferroquine in Adult Asymptomatic Plasmodium Falciparum Carriers
|
Phase 1 | |
| Completed |
NCT03387631 -
Efficacy And Safety Of AL For The Treatment Of Uncomplicated Falciparum Malaria In Mainland Tanzania
|
N/A | |
| Completed |
NCT00868465 -
Treatment Efficacy and Malaria TRANSmission After Artemisinin Combination Therapy (TRANSACT)
|
N/A | |
| Completed |
NCT00459615 -
Phase II Dose Ranging Study of Artesunate
|
Phase 2 | |
| Completed |
NCT00460369 -
Treatment of Uncomplicated Malaria in Benin
|
N/A |