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Hyperbaric Oxygen Therapy for Ulcerative Colitis — HBOT-UC  

Ulcerative Colitis Clinical Trial

Official title:
Hyperbaric Oxygen Therapy for Ulcerative Colitis Patients Hospitalized for Moderate to Severe Flares: A Multi-Center, Randomized, Double-Blind, Sham-Controlled Trial

Clinical Trial Summary

Chronic intestinal hypoxia and accompanying mucosal inflammation is a hallmark of ulcerative colitis (UC). Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen under increased atmospheric pressure to increase tissue oxygenation. Two small prospective randomized controlled trials have demonstrated that the delivery of HBOT to UC patients hospitalized for acute moderate to severe flares results in improved remission rates and avoidance of in-hospital progression to biologics, small molecules, or colectomy. In this larger trial the study aims to confirm the treatment benefits of HBOT for hospitalized UC patients and study the immune-microbe mechanisms underpinning treatment response.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05987852
Study type Interventional
Source Northwestern University
Contact Yasmin Pina, BS
Phone 312-503-6459
Email yasmin.pina@northwestern.edu
Status Recruiting
Phase N/A
Start date January 9, 2024
Completion date September 1, 2027
View Details
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