Nicotinamide Riboside in Ulcerative Colitis

Status Recruiting

Clinical Trial Summary

This is a randomized, double-blind pilot study of Nicotinamide Riboside (NR) in Pediatric-onset Ulcerative Colitis (UC).

Clinical Trial Description

The investigators hypothesize that NR will alleviate mitochondrial dysfunction and restore metabolic homeostasis in the intestinal epithelium in pediatric patients with UC. The purpose of the study are: 1. To establish the feasibility of an Randomized Clinical Trial (RCT) investigating the effects of NR in pediatric patients with UC. 2. To evaluate the effects of Nicotinamide adenine dinucleotide (NAD)+ repletion on intestinal epithelial mitochondrial structure and function in human UC patients. The investigators hypothesize that daily NR supplementation will restore NAD+ levels, enhancing Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) activity and mitochondrial structure/function. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05561738
Study type	Interventional
Source	University of Pittsburgh
Contact	Min Shi
Phone	412-692-6272
Email	shim@upmc.edu
Status	Recruiting
Phase	N/A
Start date	February 28, 2024
Completion date	December 31, 2025

View Details

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