Inflammatory Bowel Diseases Remission Registry

Ulcerative Colitis Clinical Trial

Official title: The Inflammatory Bowel Diseases Remission Registry

Status Recruiting

Clinical Trial Summary

The inflammatory bowel diseases (IBDs), ulcerative colitis (UC) and Crohn's disease (CD), are characterized by lifelong relapsing-remitting gastrointestinal inflammation, with symptoms of abdominal pain, diarrhea, and rectal bleeding during active disease. Medical therapy reduces intestinal inflammation and ameliorates symptoms. Clinical remission is defined when symptoms are resolved. In these periods, patients are able to perform daily activities more freely and lead a normal lifestyle. Biochemical remission (normalization of CRP and fecal Calprotectin) and endoscopic remission (no visual signs of inflammation of the mucosa in endoscopy) are the goals of IBD treatment.

Unfortunately, 30-40% of patients will relapse during 6 months from achieving remission. Risk factors for disease exacerbation are still unknown, and no guidelines exist as to the prevention of relapse and maintenance of remission in IBD patients.

In addition to the above, sleep disturbances and disturbances in the circadian rhythm can be a potential cause of flare-up. Sleep disorders cause changes in immune function, which later affect the course of the disease in IBD. This back affects the sleep pattern, so that a cycle is created, which may perpetuate the inflammation.

The interactions between sleep and inflammation are complex. An effective immune system affects sleep, and sleep disorders affect the functioning of the immune system. Furthermore, changes in the biological clock and sleep deprivation have been directly shown to worsen ulcerative colitis in laboratory animals. In people with sleep disorders, high levels of inflammation were found.

However, it is difficult to dissect the cause and effect for these associations, given their complex interactions.

Therefore we are planning to conduct a prospective study to assess variety of factors that might be associated with the activity of IBD.

Clinical Trial Description

Prospectively follow IBD patients in remission (both clinical and biochemical) until disease exacerbation.

• Specific aims:

• To detect risk factors and early signs for disease exacerbation in IBD patients.

• To detect predictors of disease exacerbation from environmental and behavioral characteristics of patients, clinical and biochemical characteristics of the disease.

• To examine whether changes in circadian rhythm are associated with improvement in clinical and biological disease activity

Study design:

• A prospective cohort study. Eligible patients will be follow up for at least one year or until relapse time.

• Setting: prospectively collect clinical, behavioral, dietary and environmental data of IBD patients currently declared in an endoscopic remission according to the criteria in Israel. Data will be collected according to a uniform standardized protocol specifically adapted to the needs of the study. The team will include members of the IBD clinic at the Tel Aviv Medical Center, run by Dr. Nitsan Maharshak.

Study population:

Eligible IBD patients treated at the IBD clinic in the Tel Aviv Medical Center participating in the study, which have signed an informed consent form and answered to all the study inclusion criteria. Patients will be informed of the study by their treating physician, recruited and followed throughout the follow-up period by study co-ordinators. ;

Related Conditions & MeSH terms

• Crohn Disease
• Inflammatory Bowel Diseases
• Pouchitis
• Ulcerative Colitis

• NCT number: NCT04912999
• Study type: Observational [Patient Registry]
• Source: Tel-Aviv Sourasky Medical Center
• Contact: Nitsan Maharshak, Professor
• Phone: 972-36972428
• Email: nitsanm@tlvmc.gov.il
• Status: Recruiting
• Start date: August 1, 2019
• Completion date: May 1, 2026