Ulcerative Colitis Clinical Trial
Official title:
Analysis of Intestinal Defensin Expression in Patients With Acute Graft-versus-Host Disease (GVHD)
Verified date | August 2023 |
Source | University of Freiburg |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This study has the aim to analyze intestinal expression of endogenous antimicrobial peptides in patients with acute GVHD. The expression will be compared to intestinal expression of defensins in patients with colitis and patients without intestinal inflammation.
Status | Active, not recruiting |
Enrollment | 80 |
Est. completion date | December 31, 2024 |
Est. primary completion date | December 31, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 99 Years |
Eligibility | Inclusion Criteria: - age = 18 years - diagnostic endoscopy was performed - diagnosis results available - written informed consent - ability to understand the nature of the study and the study related procedures and to comply with them Exclusion Criteria: - age < 18 years - gastrointestinal cancer - lack of informed consent |
Country | Name | City | State |
---|---|---|---|
Germany | Medical Center University of Freiburg | Freiburg | Baden-Württemberg |
Lead Sponsor | Collaborator |
---|---|
University of Freiburg |
Germany,
Kohler N, Zeiser R. Intestinal Microbiota Influence Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation and Intestinal GVHD. Front Immunol. 2019 Jan 17;9:3179. doi: 10.3389/fimmu.2018.03179. eCollection 2018. — View Citation
Wehkamp J, Fellermann K, Herrlinger KR, Baxmann S, Schmidt K, Schwind B, Duchrow M, Wohlschlager C, Feller AC, Stange EF. Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2002 Jul;14(7):745-52. doi: 10.1097/00042737-200207000-00006. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Defensin Expression (mRNA) | Analysis of alpha-defensin and beta-defensin mRNA expression by realtime PCR (qRT-PCR) | 3 years | |
Primary | Defensin Expression (peptide) | Analysis of alpha-defensin and beta-defensin levels by immunohistochemistry | 3 years |
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