Autoimmune Protocol Diet and Inflammatory Bowel Disease

Ulcerative Colitis Clinical Trial

Official title: Efficacy of the Autoimmune Protocol Diet for Inflammatory Bowel Disease

Status Completed

Clinical Trial Summary

There is limited data to guide the use of dietary change in the management of IBD, and it can prove challenging to implement in the setting of altered anatomy, comorbid conditions, and patient compliance. Therefore there is an important need to study diet as a therapy for IBD. Here, the investigators propose a novel study to evaluate the feasibility and efficacy of the autoimmune protocol (AIP) diet in patients with active Crohn's disease (CD) and ulcerative colitis (UC).

Clinical Trial Description

The investigators propose a novel study to evaluate the feasibility and efficacy of the autoimmune paleo (AIP) diet in patients with Crohn's disease (CD) and ulcerative colitis (UC).

Specific aims:

1. To evaluate the effect of the AIP diet on clinical and endoscopic disease activity for CD and UC,

2. To examine changes in inflammatory biomarkers during AIP diet

3. To characterize changes in RNA expression from intestinal mucosal biopsy specimens from prior to diet initiation to end of the study.

4. To characterize changes in fecal microbiome during diet intervention ;

Related Conditions & MeSH terms

• Colitis, Ulcerative
• Crohn Disease
• Inflammatory Bowel Diseases
• Intestinal Diseases
• Ulcerative Colitis

• NCT number: NCT03512327
• Study type: Interventional
• Source: Scripps Health
• Status: Completed
• Phase: N/A
• Start date: September 1, 2016
• Completion date: December 10, 2016