Ulcerative Colitis Clinical Trial
Official title:
Prevalence of Cytomegalovirus, Epstein Barr Virus and Human Herpes 6 Virus DNA in Intestinal Mucosa of Patients With Inflammatory Bowel Disease
An increase prevalence of CMV, EBV and or HHV-6 in diseased tissue of inflammatory bowel disease would suggest a role for these viruses in the etiology and/or exacerbation of IBD, whereas their absence would preclude such association.
The protocol is designed to evaluate the following objectives:
1. The prevalence of cytomegalovirus, Epstein Barr virus and human herpes 6 virus DNA in
inflamed intestinal mucosa of patients with Crohn's colitis and ulcerative colitis
compared to their prevalence in healthy intestinal mucosa of patients not affected by
these conditions;
2. To evaluate the prevalence of cytomegalovirus, Epstein Barr virus and human herpes 6
virus DNA in the intestinal mucosa of patients with Crohn's colitis and ulcerative
colitis compared to that in inflamed mucosa caused by other conditions (non specific
colitis);
3. To compare the prevalence of cytomegalovirus, Epstein Barr virus and human herpes 6
virus DNA in inflamed and healthy tissue in the same patients with Crohn's colitis and
ulcerative colitis;
4. To determine whether the presence of cytomegalovirus, Epstein Barr virus and human
herpes 6 virus DNA detected by nPCR correlates with immunohistochemical detection of
viral protein in colonic tissue.
5. To determine whether the relative viral quantity of CMV, EBV or HHV-6 is related to
severity of disease activity.
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Observational Model: Case Control, Time Perspective: Prospective
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