Type2 Diabetes Clinical Trial
Official title:
The Effect of Non-surgical Periodontal Therapy on Serum Resistin Level in Chronic Periodontitis Patients With or Without Type 2 Diabetes Mellitus
non-surgical periodontal debridement was performed for diabetic patients with chronic periodontitis as well as for non-diabetic patients but also with chronic periodontitis. Serum resistin level was assessed in the two groups before and after periodontal therapy and also was compared to a healthy control group.
Background: Resisitin is a recognized marker for chronic inflammatory conditions that could
be directly linked with type 2 diabetes mellitus. The aim of this study was to assess serum
resistin level in type 2 diabetic patients with chronic periodontitis.
Methods: Forty individuals were recruited in this study and were divided into three groups,
diabetic group consisted of 15 diabetic patients (type 2 diabetes mellitus) with moderate to
severe chronic periodontitis, non-diabetic group consisted of 15 non-diabetic patients with
moderate to severe chronic periodontitis and healthy group consisted of 10 non-diabetic
individuals with healthy periodontium. Non-surgical periodontal therapy with supra and
subgingival debridement was performed for the diabetic and non-diabetic groups. Pocket depth,
clinical attachment level, plaque index, gingival index, serum Resistin and high sensitivity
C-Reactive Protein assay were recorded for both groups before and after treatment, while
HbA1c was recorded for the diabetic group.
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