Type2 Diabetes Clinical Trial
Official title:
1.2% Rosuvastatin Subgingivally Delivered In Treatment Of Chronic Periodontitis With Type 2 Diabetes Mellitus: A Placebo Controlled Clinical Trial
The purpose of the present study was to evaluate the effects of subgingival delivery of 1.2% Rosuvastatin (RSV) gel as an adjunct to scaling and root planing in chronic periodontitis (CP) with Type 2 diabetes mellitus patients.
Background: The purpose of this double-masked, randomized, controlled clinical trial was to
evaluate the effects of subgingival delivery of 1.2% Rosuvastatin gel as an adjunct to
scaling and root planing (SRP) on clinical and radiographic parameters and compare this
method with SRP plus placebo gel alone in chronic periodontitis (CP) with type 2 DM
patients.
Methods: Eighty CP patients with type 2 DM are included in this study. They were divided
into two groups: 1) SRP + 1.2% Rosuvastatin gel (RSV group); 2) SRP + Placebo gel (Placebo
group). At baseline, 3, 6 and 9 months after treatment, clinical measurements, including
plaque index (PI), modified sulcus bleeding index (mSBI), probing depth (PD), clinical
attachment level (CAL) and radiographic parameters intrabony defect depth (IBD), percentage
change in radiographic defect depth reduction (DDR%) were assessed.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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