Type2 Diabetes Clinical Trial
Official title:
Does Urinary C-peptide Creatinine Ratio Predict Response to Incretin Based Agents in Type 2 Diabetes
Type 2 diabetes is a major and rapidly increasing health problem worldwide. Keeping the blood
glucose (sugar) from going too high helps prevent complications. Recently a number of new
treatments (collectively called 'incretin based' treatments) to lower blood glucose have
become available but response is very variable and it is difficult to predict which will work
for an individual. The investigators want to see if we can identify whether the new
treatments are likely to be effective for an individual patient. Identifying the right
treatment would improve control and minimise the side-effects and costs from ineffective
treatments. We will collect blood (for measures of blood glucose, insulin secretion and
genetics information), urine (for a simple measurement of insulin secretion) and other
clinical information (such as weight,age, duration of diabetes and medication) in people who
are about to start these new 'incretin based' treatments and assess their response over the
first 6 months of treatment. We will analyse this information to see if we can predict
treatment response.
Study Hypothesis:
The investigators hypothesise that those who have low insulin secretion, as measured by post
meal urine C-peptide Creatinine Ratio or blood C-peptide, will have poor blood glucose
response to incretin based treatments.
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