Brown Adipose Tissue in Type 1 Diabetes

Type1diabetes Clinical Trial

Official title:

Studies of Activity of Brown Adipose Tissue With Positron Emission Tomography Using the Tracer 18F-deoxy Glucose in Patients With Type 1 Diabetes

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02984514
• Other study ID #: Dnr 2015/191
• Status: Completed
• Phase: N/A
• Start date: October 2015
• Est. completion date: June 2018

Study information

• Verified date: October 2018
• Source: Uppsala University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Brown adipose tissue has the capacity to consume large amounts of energy and has insulin-independent glucose uptake. The investigators have recently observed an inverse correlation between irisin levels and insulin needs of type 1 diabetes patients. Transplantation of brown adipose tissue to insulin-deficient rats normalized their blood glucose levels.

In this study 12 patients with long-standing type 1 diabetes (>10 years) and with variable exogenous insulin needs will be investigated for amount of brown adipose tissue with positron emission tomography using the tracer 18F-deoxy glucose.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 11
• Est. completion date: June 2018
• Est. primary completion date: January 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Adult patients (18 years of age or more)

2. Type 1 diabetes diagnose for more than 10 years

Exclusion Criteria:

1. Ongoing pregnancy

2. Ongoing breast-feeding

3. BMI<19

4. BMI >30

5. P-creatinine <110 µmol/l

Related Conditions & MeSH terms

• Diabetes Mellitus
• Diabetes Mellitus, Type 1
• Type1diabetes

Intervention

Radiation:
• Positron emission tomography with tracer 18F-deoxy glucose
Assessment of activity of brown adipose tissue with positron emission tomography using the tracer 18F-deoxy glucose

Locations

Country	Name	City	State
Sweden	Uppsala University Hospital	Uppsala

Sponsors (1)

Lead Sponsor	Collaborator
Per-Ola Carlsson

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Activity of brown adipose tissue in correlation to exogenous insulin needs using the tracer 18F-deoxy glucose in positron emission tomography measurements		Assessment performed after more than 10 years of diagnosed type 1 diabetes
Secondary	Glucose uptake in muscle in correlation to exogenous insulin needs; assessment using the tracer 18F deoxy glucose in positron emission tomography measurements.		Assessment performed after more than 10 years of diagnosed type 1 diabetes