Type II Diabetes Mellitus Clinical Trial
Official title:
Protocol 2: Elucidation of Mechanisms Responsible for the Increase in EGP Following SGLT2 Inhibition: Decrease in Plasma Glucose Conc or Change in Islet Hormone (Glucagon/Insulin) Secretion
In Protocol 2, the investigators will determine the role of pancreatic hormones (increase in plasma glucagon and decrease in plasma insulin concentration) in the stimulation of EGP following SGLT2 inhibition.
The inhibition of the renal (kidney) SGLT2 transporter has proven to be an effective
therapeutic intervention to reduce plasma glucose levels (amount of glucose found in the
liquid part of blood) and HbA1c.
In this study, the investigators hope to define the role of increased plasma glucagon,
decline in plasma insulin, and fall in plasma glucose concentration. The investigators will
examine whether the signal for the increase in EGP (endogenous glucose production) caused by
glucosuria (an excess of sugar in the urine, typically associated with diabetes) is mediated
via the decrease in plasma glucose and insulin concentrations, or by the increase in plasma
glucagon concentration.
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