Type 2 Diabetes Mellitus (T2DM) Clinical Trial
Official title:
Clinical Mechanism of Endovascular Denervation (EDN) for the Treatment of Type 2 Diabetes
This is a prospective, single-center, single-arm, self-controlled study to evaluate the effects of endovascular denervation (EDN) on insulin secretory function and insulin sensitivity in the treatment of type 2 diabetes mellitus (T2DM) .
This is a prospective, single-center, single-arm, self-controlled study. Patients with diagnosed T2DM and poor glycemic control (i.e.. glycated hemoglobin A1c (HbA1c) between 7.5% and 10.5% despite one to three oral antidiabetic drugs (OAD) and/or insulin on the basis of metformin. All included subjects will accept EDN treatment and were followed up at 7, 30 days and 3, 6, 12 months. The primary objectives were evaluate the effects of EDN on insulin secretory function and insulin sensitivity in the treatment of T2DM. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05102149 -
Study to Evaluate the Safety and Efficacy of PB-201 in Treatment-naive Patients With Type 2 Diabetes Mellitus
|
Phase 3 | |
| Withdrawn |
NCT03423355 -
Dapagliflozin Effect on Erythropoiesis and Physical Fitness
|
Phase 4 | |
| Terminated |
NCT01923389 -
Multiple Dose Study Of PF-05231023 In Obese Adult Subjects
|
Phase 1 | |
| Completed |
NCT02218099 -
A Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety of ASP8232 in Subjects With Renal Impairment and in Type 2 Diabetes Mellitus Subjects With Chronic Kidney Disease
|
Phase 1/Phase 2 | |
| Completed |
NCT05607160 -
A Study to Observe How Insulin Glargine 300 U/ml is Working and is Tolerated in Elderly Patients ≥75 Years of Age With Type 2 Diabetes
|
||
| Completed |
NCT05628090 -
A Study of an Existing Database to Assess the Treatment Persistence to Basal Insulin in Type 2 Diabetes Mellitus Patients in a Structured Patient Education Program in India
|
||
| Completed |
NCT03656744 -
A Study of HTD1801 in Adults With Nonalcoholic Steatohepatitis (NASH) and Type 2 Diabetes Mellitus (T2DM)
|
Phase 2 | |
| Completed |
NCT01002807 -
Bioavailability Study of Fixed Dose Combination (FDC) Formulations of Dapagliflozin and Metformin XR Versus Individual Component Coadministered to Healthy Subjects in a Fasted State
|
Phase 1 | |
| Recruiting |
NCT04943861 -
Human Immunodeficiency Virus (HIV) Food Insecurities
|
N/A | |
| Completed |
NCT02759107 -
A Study of Tirzepatide (LY3298176) in Healthy Participants and Participants With Type 2 Diabetes (T2DM)
|
Phase 1 | |
| Completed |
NCT02643797 -
Medical Assistant Health Coaching for Diabetes in Diverse Primary Care Settings
|
Phase 3 | |
| Completed |
NCT05294458 -
A Randomised, Open-Label Study to Evaluate the Relative and Absolute Bioavailability of Cotadutide in Healthy Subjects
|
Phase 1 | |
| Recruiting |
NCT06327815 -
Efficacy of FDC Regimen of Dapagliflozin/Metformin Compared to Co-administered Dual Therapy on Glycemic Control, Satisfaction and Adherence in Chinese Patients With T2DM
|
Phase 4 | |
| Completed |
NCT02219646 -
Diabetes & Vardenafil
|
Phase 2 | |
| Recruiting |
NCT05761301 -
A Phase 1/2 Study to Evaluate ALN-KHK in Overweight to Obese Healthy Volunteers and Obese Patients With T2DM
|
Phase 1/Phase 2 | |
| Completed |
NCT04504396 -
Safety and Efficacy of PB-119 in Subjects With Type 2 Diabetes and Not Well-controlled by Metformin Monotherapy
|
Phase 3 | |
| Completed |
NCT01991093 -
Multiple Electrode Aggregometry & Clopidogrel Resistance
|
||
| Completed |
NCT01871558 -
Vildagliptin/Metformin in T2DM Patients Starting Basal Insulin
|
Phase 3 | |
| Completed |
NCT01407003 -
Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) Assessment of LIK066 in Healthy Subjects and in Patients With Type 2 Diabetes Mellitus (T2DM)
|
Phase 1/Phase 2 | |
| Completed |
NCT01127308 -
A Radiolabeled Mass Balance Study of [14C]-Ertugliflozin (PF04971729, MK-8835) In Healthy Male Participants (MK-8835-038)
|
Phase 1 |