Glucagon Enhanced Insulin Absorption in Diabetes Mellitus Type 1

Status Recruiting

Clinical Trial Summary

The investigators will study the effect of microdoses of glucagon at the site of subcutaneous insulin injection. The investigators have unpublished data from anesthetized pigs indicating a major enhancement of insulin absorption.

Clinical Trial Description

People with type 1 diabetes will come fasting in the morning to the research facility on two separate days. Both days participants will have a breakfast of their own choice and their regular dose of meal insulin injected. Lyumjev will be used. Frequently collected blood sampled will be analysed for glucose, insulin and glucagon for 3.5 hours. The procedures will be exactly the same both days except that on one of the days they will be randomised to a small dose of glucagon that will be injected at exactly the same site as Lyumjev insulin is injected. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05960565
Study type	Interventional
Source	St. Olavs Hospital
Contact	Sven M Carlsen, MD, PhD
Phone	+47 91769528
Email	sven.carlsen@ntnu.no
Status	Recruiting
Phase	Phase 2
Start date	June 20, 2023
Completion date	June 30, 2024

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