Type 1 Diabetes Clinical Trial
Official title:
Dual-Hormone Closed-Loop Glucose Control in Type 1 Diabetes
The ultimate T1D treatment tool is a closed-loop glucose control system, i.e. a fully
automated system for intensive insulin treatment. Such system will ease the burden of
constant treatment decision-making and at the same time it has the potential to safely
intensify insulin therapy such that more patients can reach treatment goals. Currently, no
off-the-shelf closed-loop system exists but research efforts in this field have been
intensified and resulted in great progress in recent years. Most closed-loop systems consist
of an insulin pump, a CGM, and a control algorithm residing on a mobile computer that
continuously (every 5-15 min) computes the optimal insulin dosage from the CGM values. For
daytime blood glucose control, however, we believe that the system needs to be further
advanced. Consequently, we have extended our single-hormone closed-loop system such that it
now includes a second pump for glucagon delivery and correspondingly we have further
developed our control algorithm to compute both insulin and glucagon dosages.
We hypothesize that we have developed a safe and effective dual-hormone closed-loop system
for patients with type 1 diabetes and that this system is superior to single-hormone
closed-loop therapy. The aims of this two-phase project are to 1) demonstrate
proof-of-concept and 2) to compare dual-hormone with single-hormone closed-loop glucose
control.
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