Hyaluronidase Effect on Infusion Set Life

Status Completed

Clinical Trial Summary

This research study examines the effect of hyaluronidase on the length of time of insulin infusion set wear. The aim of the study is to improve the length of time that an infusion set can be worn by infusing hyaluronidase directly into the insulin infusion site.

Clinical Trial Description

The investigators would like to see if the use of hyaluronidase will improve insulin infusion set survival and improve the onset of insulin action. The investigators will also assess the accuracy of the Dexcom G4P sensors with extended site use beyond the 7 day FDA approved time frame.

The use of sensor information combined with the knowledge of infused insulin from pump therapy could potentially help us detect when an infusion set is beginning to fail. Information from the sensor function to the point of failure, and sensor function in response to Tylenol may allow us to develop special formulas to determine when a sensor is not working well. This will be very important for creating an artificial pancreas.

Thirty subjects will be enrolled. Fifteen patients from each of the two sites: Stanford University and University of Colorado. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02199028
Study type	Interventional
Source	Stanford University
Contact
Status	Completed
Phase	Phase 1
Start date	July 2014
Completion date	March 2015

View Details

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