Type 1 Diabetes Mellitus Clinical Trial
Official title:
Gene Expression Profiling in Type 1 Diabetes
One of the goals of the Kansas City Diabetes Consortium is to identify and characterize
genes and their products that are associated with T1DM. Characterization of such genes and
their products can aid in developing new tools for risk assessment, development of new
prevention strategies and monitoring progression of disease.
Study design: Descriptive, basic science pilot study. The results of this pilot study will
be used to help design a much larger study to address the importance of viral response and
autoimmune diabetes.
The hypothesis is that viral responsive genes are up-regulated prior to the onset of
symptoms of Type 1 Diabetes (T1DM) and may correlate with increased expression of interferon
alpha.
Both genetic and environmental factors contribute to risk of development of T1DM. There are
a number of conflicting reports associating viral infections and T1DM in genetically
susceptible individuals and causality has not been proven. Viruses may not have a large role
in the initiation of islet cell autoimmunity but more of a role in acceleration of the
disease leading to overt symptoms. There are no studies describing viral responsive gene
expression in these individuals.
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Observational Model: Case Control, Time Perspective: Prospective
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