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Tympanic Membrane Perforation clinical trials

View clinical trials related to Tympanic Membrane Perforation.

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NCT ID: NCT06260618 Recruiting - Surgery Clinical Trials

Effect of Chitodex Gel in Tympanoplasty Surgery

Start date: November 20, 2021
Phase: N/A
Study type: Interventional

The general purpose of this study is to compare Chitosan-dextran (Chitodex) gel versus current standard of care, Gelfoam, as a middle ear (ME) and external auditory canal (EAC) packing agent as part of tympanoplasty procedures to close tympanic membrane perforations (TMP).

NCT ID: NCT06257602 Not yet recruiting - Clinical trials for Tympanic Membrane Perforation

Microscopic Versus Endoscopic Tympanoplasty

Start date: March 30, 2024
Phase:
Study type: Observational

In this study, The investigatirs will compare surgical and anatomical outcomes of endoscopic and microscopic tympanoplasty type 1(myringoplasty) using tragal perichondrum and cartilage, and conduct a post-treatment survey regarding: 1. Graft uptake, hearing outcome, postoperative pain, and healing time. 2. Assess the operation time.

NCT ID: NCT05993039 Recruiting - Perforated Eardrum Clinical Trials

Inhalational Anesthesia vs TIVA in Endoscopic Tympanoplasty

TIVA
Start date: September 1, 2023
Phase: Early Phase 1
Study type: Interventional

This study aims to prospectively compare surgical field quality and intraoperative blood loss between general inhalational anesthesia to total intravenous anesthesia (TIVA) alone in subjects undergoing endoscopic ear surgery. A secondary objective is to compare rates of emergence delirium and total recovery time between the two groups.

NCT ID: NCT05849844 Recruiting - Clinical trials for Tympanic Membrane Perforation

Tympanoseal Clinical Study

Start date: January 5, 2024
Phase: N/A
Study type: Interventional

The purpose of this investigational study is to assess the ability of Tympanoseal (sodium/calcium alginate), an investigational device, to act as a scaffold during healing of the tympanic membrane. Tympanoseal is intended for use following removal or extrusion of indwelling tympanostomy tubes or traumatic injury of the tympanic membrane.

NCT ID: NCT05605262 Completed - Clinical trials for Tympanic Membrane Perforation

Effects of 100% Medical Grade Manuka Honey on Tympanic Membrane Reconstruction Healing.

Start date: June 13, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

Throughout history, honey has been recognized for its healing properties. The use of honey for its medicinal properties dates back to 2200 BCE. The purpose of this clinical trial is to learn about the healing effects of 100% medical grade Manuka honey in participants with Chronic Suppurative Otitis Media of the mucosal type. The main question it aims to answer is: Can 100% Manuka honey given at the time of Tympanoplasty improve the re-epithelialization (healing process) of the tympanic membrane compared to controls? Participants in the intervention group will receive a wound dressing of 100% medical grade Manuka honey after reconstructive surgery of the tympanic membrane. Researchers will compare the intervention group to the control group to see healing process.

NCT ID: NCT05282810 Not yet recruiting - Clinical trials for Tympanic Membrane Perforation

Cartilage Versus Temporalis Fascia Graft in Tympanoplasty for Recurrent Tympanic Membrane Perforation '' Comparative Study ''

Start date: April 2022
Phase:
Study type: Observational

Use of Cartilage Versus Temporalis Fascia as a Graft in Tympanoplasty for Recurrent Tympanic Membrane Perforation

NCT ID: NCT05086718 Recruiting - Clinical trials for Tympanic Membrane Perforation

Composite Cartilage Perichondrium Graft for Air Bone Gap Closure in Chronic Suppurative Otitis Media (CSOM) Without Posterior Meatal Flap

Start date: September 1, 2021
Phase: N/A
Study type: Interventional

Composite Cartilage Perichondrium Graft for tympanoplasty in chronic suppurative otitis media (CSOM) Air Bone Gap (AB Gap) Closure will be taken as successful outcome Endoscopic technique without posterior meatal flap elevation

NCT ID: NCT04960384 Recruiting - Clinical trials for Tympanic Membrane Perforation

Fibroblast Growth Factor Regeneration of Tympanic Membrane Perforations

Start date: May 27, 2022
Phase: Phase 2
Study type: Interventional

This study is a double blinded, placebo-controlled phase II study evaluating the efficacy of FGF-2 for the treatment of chronic non-healing tympanic membrane perforations (TMP). The documentation of TM closure will be the main efficacy outcome measure. Pretreatment photographs will document the area of the TM perforation and allow measurement of surface areas of the TMP for comparison of pre- and post-treatment. The study will be divided into two phases, the Randomized Treatment phase (part A), and the Unblinded Crossover phase (part B). In part A of the study, subjects will be randomized 1:1 (using simple randomization) to receive FGF-2 or placebo treatment up to 3 treatments. Subjects that fail three study treatments will move on to part B of the study. Subjects who received placebo in part A and failed three placebo treatments will crossover to receive unblinded FGF-2 for up to 3 treatments. Subjects who received FGF-2 in part A and failed three experimental treatments will not have additional FGF-2 treatment, and will move on to study follow up.

NCT ID: NCT04761562 Recruiting - Clinical trials for Tympanic Membrane Perforation

Use of Autologous Plasma Rich in Platelets and Extracellular Vesicles in the Surgical Treatment of Chronic Middle Ear Infections

Start date: February 14, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

This clinical study evaluates the efficacy of the autologous blood-derived product called platelet- and extracellular vesicle-rich plasma as a supplement to the surgical treatment of chronic tympanic membrane perforations. Half of the participants will be treated with standard surgical procedure called tympanoplasty and addition of platelet- and extracellular vesicle-rich plasma. Another half will be treated with only the standard tympanoplasty.

NCT ID: NCT04687995 Not yet recruiting - Clinical trials for Tympanic Membrane Perforation

Tragal Perichondrium Versus Pretragal Fascial (SMAS) Graft for Endoscopic Myringoplasty

Start date: January 2021
Phase: N/A
Study type: Interventional

1. Examine the treatment outcomes of the pretragal (SMAS) fascia as a new graft when used in endoscopic myringoplasty. 2. Compare the results when using the tragal pericondrium as a graft in endoscopic myringoplasty regarding donor site and success.