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Clinical Trial Summary

The purpose of this study is to determine whether aprepitant can be used in the Cisplatin - Etoposide chemotherapeutic regimen.


Clinical Trial Description

Aprepitant acts initially as a moderate inhibitor of CYP3A4 followed by a short period of CYP3A4 induction. Etoposide is a substrate of CYP3A4 and may therefore be suvject to a drug interaction with aprepitant. CE can be classified as a highly emetogenic chemotherapeutic regimen and the use of aprepitant may therefore be considered when no clinically relevant drug interaction with etoposide can be determined. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT00588835
Study type Interventional
Source Radboud University
Contact
Status Terminated
Phase Phase 4
Start date March 2008
Completion date January 2010

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