Tuberculosis, Pulmonary Clinical Trial
Official title:
Evaluation of 11C-acetate PET Imaging as a Novel Approach to Detecting Pathology in Pulmonary TB
Imaging using 11C-acetate PET (positron emission tomography) in patients with tuberculosis (TB) may be able to detect non-replicating persister bacilli. This may permit identification of those patients at risk of relapse following completion of TB treatment. The main aim of this pilot study is to assess the ability of 11C-acetate PET to detect pulmonary lesions in individuals with active pulmonary TB.
Status | Recruiting |
Enrollment | 5 |
Est. completion date | |
Est. primary completion date | September 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 21 Years and older |
Eligibility |
Inclusion Criteria: 1. Age 21 years and above 2. Willing to comply with the study visits and procedures 3. Willing and able to provide written informed consent 4. Clinical diagnosis of pulmonary TB with characteristic symptoms and compatible X-ray findings plus microbiological confirmation with one or more of (i) Acid-fast bacilli (AFB) smear-positive or (ii) molecular test positive or (iii) TB culture positive. Tests done at any time during the current episode of TB are acceptable for diagnostic purposes 5. Not on TB treatment or have completed less than 8 weeks of TB treatment Exclusion Criteria: 1. Diabetes that is, in the judgment of the investigator, so poorly controlled that it would prevent adequate PET scanning 2. Cardiac pacemaker, aneurysm clip or other metallic implant considered unsafe for MRI 3. Known chronic kidney disease 4. Occupation involving substantial exposure to radiation 5. History of medical procedures in the last year involving substantial exposure to radiation (>2mSv) 6. Malignancy requiring chemotherapy or radiation 7. Women who are currently pregnant or breastfeeding |
Country | Name | City | State |
---|---|---|---|
Singapore | National University Hospital | Singapore | |
Singapore | Tan Tock Seng Hospital | Singapore |
Lead Sponsor | Collaborator |
---|---|
National University Hospital, Singapore |
Singapore,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Standard uptake value (SUV) of 11C-acetate PET in pulmonary TB lesions | Within 8 weeks of starting TB treatment |
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