Tuberculosis Clinical Trial
Official title:
Optimization of Tuberculosis Diagnosis and Management Using Four Immunological Biomarkers
Tuberculosis (TB) is the leading cause of death by infectious disease in the world,
responsible for 1.6 million deaths in 2017. The treatment of active TB requires at least a
6-month combined antibiotic regimen and can cause heavy side effects. As a consequence,
treatment adherence is not optimal, particularly in primary care settings. Rapid and reliable
monitoring of anti-TB treatment adherence and efficacy is critical to provide adequate
patient care and curb relapse episodes and acquired drug resistance.
Investigators propose to evaluate the performance in terms of diagnosis accuracy and outcome
prediction of four new biomarkers of active TB: 1) a double IGRA (Interferon Gamma Release
Assay) including QuantiFERON-Gold Plus® and HBHA; 2) a whole blood transcriptomic analysis of
mRNA (messenger Ribonucleic acid) expression of a panel of 150 genes; 3) a whole blood
proteomic analysis; 4) an ex vivo immunophenotyping using flow and mass cytometry to
characterize the lymphocyte populations.
n/a
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