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NCT06259162 Clinical Trial

LAG3 Expression in Triple Negative Breast Cancer

Triple Negative Breast Cancer Clinical Trial

Official title:
The Evaluation the Relationship Between LAG-3 Expression / Immune Checkpoint Protein Expression and Neoadjuvant Chemotherapy Plus Immune Checkpoint Inhibitor in Triple Negative Breast Cancer

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT06259162
Other study ID # LAG3_Breast
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date November 18, 2022
Est. completion date December 31, 2027

Study information
Verified date February 2024
Source Samsung Medical Center
Contact Ji-Yeon Kim
Phone 82-2-3410-3459
Email jyeon25@skku.edu
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study is the experimental study for relationship between LAG-3 expression / immue checkpoint protein expression and neoadjuvant chemotherapy plus immune checkpoint inhibitor in triple negative breast cancer.

Recruitment information / eligibility
Status Recruiting
Enrollment 128
Est. completion date December 31, 2027
Est. primary completion date July 1, 2025
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group N/A and older
Eligibility Inclusion Criteria: - Planned neoadjuvant chemotherapy - Triple negative breast cancer Exclusion Criteria: - HER2-positive breast cancer - Hormone receptor positive breast cancer

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• LAG-3 expression / immune checkpoint protein expression
Evaluate the tissue and blood before and after chemotherapy

Locations
Country Name City State
Korea, Republic of Ji-Yeon Kim Seoul

Sponsors (1)
Lead Sponsor Collaborator
Samsung Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

Outcome
Type Measure Description Time frame Safety issue
Primary LAG-3 expression/immune checkpoint preotein expression Relationship neoadjuvant chemotherapy plus immune checkpoint inhibitor Before chemotherapy, 1 weeks & 3 weeks after chemotherapy, curative surgery
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