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PD-1 Inhibitor Concurrent With Chemotherapy as Neoadjuvant Therapy for TNBC — NeoPD1TNBC  

Triple Negative Breast Cancer Clinical Trial

Official title:
PD-1 Inhibitor Sintilimab Concurrent With Epirubicin Cyclophosphamide and Nab-paclitaxel as Neoadjuvant Therapy for Triple Negative Breast Cancer

Clinical Trial Summary

The purpose of the study is to address the following hypotheses: the PD-1 inhibitor Sintilimab 200mg for intravenous (IV) administration will be given together with three-week epirubincin, cyclophosphamide (EC) × 4 treatments from the second cycle followed by weekly nab-paclitaxel x12 treatments or three-week nab-paclitaxel x4 treatments. This regimen will induce higher pathologic complete response (pCR) rate in triple negative breast cancer than historical pCR rates (30-40%) observed with chemotherapy alone.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04809779
Study type Interventional
Source First Affiliated Hospital, Sun Yat-Sen University
Contact Nan Shao
Phone 02087755766
Email shaon@mail.sysu.edu.cn
Status Not yet recruiting
Phase Phase 2
Start date March 2021
Completion date March 2024
View Details
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