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A Study of ZEN003694 and Talazoparib in Patients With Triple Negative Breast Cancer — TNBC  

Triple Negative Breast Cancer Clinical Trial

Official title:
A Phase 2b Study of ZEN003694 in Combination With Talazoparib in Patients With Triple-Negative Breast Cancer

Clinical Trial Summary

This is a two-part open label, non-randomized, Phase 2, study of ZEN003694 in combination with Talazoparib in patients with TNBC without germline mutations of BRCA1 or BRCA2. Part 1 is a dose escalation and Part 2 is a Simon 2-Stage design. There are 3 expansion cohorts: Expansion Cohort A (combination treatment in post-TROP2-ADC patients), Expansion Cohort B (ZEN003694 monotherapy), and Expansion Cohort C (combination treatment in TROP2-ADC-naive patients).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03901469
Study type Interventional
Source Zenith Epigenetics
Contact
Status Terminated
Phase Phase 2
Start date June 26, 2019
Completion date March 7, 2024
View Details
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