Personalized Medicine in Patients With Infective Endocarditis

Status Completed

Clinical Trial Summary

The hypothesis underlying this work is the identification of different sub phenotypes of patients with infective endocarditis through the study of the host's response to infection. Furthemore, metagenomic sequencing may be a helpful supplement to IE diagnostic, especially when conventional tests fail to yield a diagnosis.

Clinical Trial Description

Infective endocarditis is a life-threatening infection of heart valves and adjacent structures characterized by vegetations on valves and other endocardial surfaces, with tissue destruction and risk of embolization. The clinical variability, including the heterogeneous response to infection and the different antibiotic treatments make the identification of the underlying pathogens of infective endocarditis (IE) is critical for precision therapy. Virulence factors mediate tissue adherence, host infiltration, immune resistance/evasion, and dynamic stress responses and confer enhanced pathogen survival, proliferation, and host invasion in animal models of infective endocarditis. To identify the microorganism and simultaneously considered the response of the host to the infection could improve the management of the infective endocarditis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04838938
Study type	Observational [Patient Registry]
Source	Fundación para la Investigación Biosanitaria del Principado de Asturias
Contact
Status	Completed
Phase
Start date	March 1, 2021
Completion date	July 1, 2023

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05243134` - The Influence of Anatomic Deformities on the Clinical Efficacy in the Patients With Patellar Dislocation
Completed	`NCT02486874` - Clinical Evaluation of PoreSkin	Phase 1
Active, not recruiting	`NCT04592640` - Stem Cells for Uremic Calciphylaxis Patients	N/A
Recruiting	`NCT04599686` - Stereotactic Body Radiotherapy (SBRT) for Oligometastatic Prostate Cancer	N/A
Recruiting	`NCT03351842` - Surgery With or Without Chemotherapy for Stage I NSCLC With Micropapillary Component ≥ 20%	Phase 2
Completed	`NCT03439930` - The Effect of Balance Training on Neuromuscular Control in Subjects With CAI	N/A
Completed	`NCT02782442` - Cognitive Training Delivered Remotely to Individuals With Psychosis (ROAM)	N/A
Not yet recruiting	`NCT05537155` - Buccal Acupuncture for Delirium Treatment in Older Patients Recovering From Orthopedic Surgery	N/A
Recruiting	`NCT02971982` - PCD Versus RCD for the Treatment of Patients With Waldenstrom's Macroglobulinemia	Phase 1/Phase 2
Completed	`NCT02820272` - Water for Reducing Pain in Negative Pressure Wound Therapy	Phase 2
Completed	`NCT00984958` - Bulkamid Treatment of Stress Incontinence in Women With Urinary Stress Incontinence and Not Suitable to TVT-procedure	N/A
Completed	`NCT00575224` - Pegasys and Copegus for Asian Patients With Treatment-naive Hepatitis C Genotypes 6, 7, 8, 9	Phase 4
Completed	`NCT00164307` - Assisting Children With Prenatal Alcohol Exposure in Developing Peer Friendships	Phase 1/Phase 2
Completed	`NCT00164528` - Intervening With Children/Adolescents With FAS/ARND	Phase 1/Phase 2
Recruiting	`NCT04603586` - Stereotactic Radiotherapy in Locally Advanced Pancreatic Cancer With Different Biological Effective Doses	N/A
Recruiting	`NCT03375424` - Vedolizumab Study With Inflammatory Bowel Disease Patients in Germany	N/A
Not yet recruiting	`NCT04062370` - Ranibizumab Treatment for Macular Edema Secondary to Retinal Vein Occlusion	Phase 4
Not yet recruiting	`NCT02931136` - Early Diagnosis and Early Treatment of Alzheimer's Disease Based on Senile Plaque Imaging	Phase 4
Completed	`NCT04661228` - Diagnostic Survey of Mental and Substance Use Disorders in HUNT (PsykHUNT)
Recruiting	`NCT03365141` - Efficacy of Intralesional Triamcinolone Injection in the Treatment of Vitiligo	N/A