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Immune Response of Visceral Leishmaniasis PatientsTreated With Antimonial Plus N-Acetylcysteine — VLNAC  

Treatment Clinical Trial

Official title:
Study for Evaluation of the Immune Response of Visceral Leishmaniasis Patients Treated With Antimonial Pentavalent Associated to N-Acetylcysteine

Clinical Trial Summary

This study is designed to evaluate the immune and therapeutic responses of visceral leishmaniasis patients using N-acetylcysteine (NAC) as an adjuvant therapy to pentavalent antimony.

Clinical Trial Description

In this study we intend to evaluate the immune and therapeutic responses of patients with visceral leishmaniasis N-acetylcysteine (NAC) as an adjuvant to standard treatment with pentavalent antimony, compared to treatment with antimonial only through a blind randomized clinical trial. Our hypothesis is that patients treated with NAC associated with pentavalent atimonial have a rapid changing of the immune responses, towards TH1, and clinical improvement when compared to patients who will use only the standard treatment ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01138956
Study type Interventional
Source Hospital Universitário Professor Edgard Santos
Contact Roque P Almeida, MD, PhD
Phone 5579-21051806
Email roquepacheco@uol.com.br
Status Recruiting
Phase N/A
Start date April 2010
Completion date December 2011
View Details
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