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Clinical Trial Summary

This application proposes to extend an ongoing NHLBI clinical trial (NCT02342808) examining the efficacy of a lifestyle intervention combining the Dietary Approaches to Stop Hypertension (DASH) diet with caloric restriction and aerobic exercise to lower and control BP in individuals with RH. In the parent trial, participants with RH will be randomized to either: (1) a 4-month adjunctive lifestyle intervention designed to lower BP through exercise and diet (C-LIFE), or; (2) a standardized education and physician advice (SEPA) control condition. The current protocol will collect additional assessments of neurocognition (executive function, processing speed, and memory), endothelial function (brachial artery flow-mediated dilation), and cerebrovascular reserve (a measure of prefrontal cortex tissue oxygenation) in 120 participants at baseline, following completion of the 4-month intervention, and again after one year, in order to examine neurocognitive improvements and their potential mediators.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT03001427
Study type Interventional
Source Duke University
Status Completed
Phase N/A
Start date January 2016
Completion date December 14, 2020

See also
  Status Clinical Trial Phase
Terminated NCT01895140 - A Study of Renal Denervation in Patients With Treatment Resistant Hypertension N/A
Completed NCT02342808 - Lifestyle Interventions in Treatment-Resistant Hypertension N/A