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Treatment-Resistant Hypertension clinical trials

View clinical trials related to Treatment-Resistant Hypertension.

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NCT ID: NCT03078244 Completed - Clinical trials for Treatment Resistant Hypertension

Protocol for a Multicentre Survey of Patients With Treatment Resistant Hypertension

SPIRIT
Start date: November 2016
Phase: N/A
Study type: Observational

Project aims to determine the number of individuals with treatment resistant hypertension and to define the characteristics of these patients and estimate disease frequency. The study will be a retrospective review of medical record data based upon deā€identified information and will require no patient contact.

NCT ID: NCT03001427 Completed - Clinical trials for Treatment-Resistant Hypertension

Neurocognition, Lifestyle Modification, and Treatment Resistant Hypertension

Start date: January 2016
Phase: N/A
Study type: Interventional

This application proposes to extend an ongoing NHLBI clinical trial (NCT02342808) examining the efficacy of a lifestyle intervention combining the Dietary Approaches to Stop Hypertension (DASH) diet with caloric restriction and aerobic exercise to lower and control BP in individuals with RH. In the parent trial, participants with RH will be randomized to either: (1) a 4-month adjunctive lifestyle intervention designed to lower BP through exercise and diet (C-LIFE), or; (2) a standardized education and physician advice (SEPA) control condition. The current protocol will collect additional assessments of neurocognition (executive function, processing speed, and memory), endothelial function (brachial artery flow-mediated dilation), and cerebrovascular reserve (a measure of prefrontal cortex tissue oxygenation) in 120 participants at baseline, following completion of the 4-month intervention, and again after one year, in order to examine neurocognitive improvements and their potential mediators.

NCT ID: NCT02342808 Completed - Clinical trials for Treatment-Resistant Hypertension

Lifestyle Interventions in Treatment-Resistant Hypertension

TRIUMPH
Start date: June 2015
Phase: N/A
Study type: Interventional

This study will examine the effects of lifestyle intervention on fitness, dietary habits, and body weight in patients with resistant hypertension (RH). Patients will be randomized to either a 4-month adjunctive lifestyle intervention designed to lower BP that will be delivered in a center-based CR program (C-LIFE), or to standardized education and physician advice (SEPA) designed to promote the same healthy behaviors and reflecting the current highest possible standard of care for promoting a healthy lifestyle in RH.