HIV-1 Infection Clinical Trial
Official title:
Management of Participants With Low-level Persistent Viremia (ANRS 161 L-VIR)
Management of participants with low-level persistent viremia
ANRS 161 L-Vir is a phase III prospective, randomized, multicenter, open-label, superiority
trial for participants with low-level persistent viremia.
Participants will be randomized with a 1:1:1 ratio to the following three arms,
- Reference arm : counseling without antiretroviral treatment modification
- Switch arm : switch of current PI/r for Prezista® (darunavir)/ Norvir® (ritonavir)
(switch for a drug with a higher genetic barrier) 600/100 mg two times a day (BID) with
counseling.
- Addition of Isentress® (raltégravir) arm : Isentress® (raltegravir) 400 mg two times a
day (BID) added to current antiretroviral treatment with counseling
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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