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Combination Therapy of Umbilical Cord Blood and Erythropoietin for Stroke Paients

Stroke Clinical Trial

Official title:
Safety and Efficacy of Combined Administration of Erythropoietin in Umbilical Cord Blood Therapy for Stroke Patients

Clinical Trial Summary

This clinical trial is a clinical trial for the evaluation of the safety and efficacy of umbilical cord blood (UCB) therapy, UCB and erythropoietin (EPO) combination therapy in adult stroke patients.

Clinical Trial Description

UCB is a high-quality source of mesenchymal stem cells, and studies are being actively developed for stroke patients. UCB therapy has a neuroprotective effect through anti-inflammatory effect and anti-apoptosis. However, UCB alone has not been able to provide sufficient improvement and is being studied for combination therapies with growth factors that can exert its effects. Among the various growth factors, EPO is a powerful factor that can act as a neurotrophic factor in neurons, astrocytes, oligodendrocytes, microglia, endothelial cells, and neural stem/precursor cells. In our previous study of subacute stroke animal models, investigators confirmed that the combined administration of UCB and EPO improved the behavioral assessment (mNSS, Cylinder test) compared to UCB only administration. The aim of this study is to investigate the difference in therapeutic effects between UCB alone therapy and UCB and EPO combination therapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04013646
Study type Interventional
Source Bundang CHA Hospital
Contact Jong Moon Kim, MD
Phone 82-31-870-5456
Email jmkim1013@gmail.com
Status Recruiting
Phase Phase 1/Phase 2
Start date May 2, 2019
Completion date November 2, 2021
View Details
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