Traumatic Brain Injury Clinical Trial
Official title:
Evidence Based Diagnostics and Treatment Planning Solution for Traumatic Brain Injuries - the TBIcare Project
Verified date | May 2015 |
Source | Turku University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | Finland: Finnish Medicines Agency |
Study type | Observational |
Adult patients, age ≥ 18 years, with clinically diagnosed mild, moderate or severe brain trauma will be asked to participate in the study. This prospective database will consist of 400 subjects with TBI, 200 from both TUCH and Cambridge Addenbrooke's Hospital. In addition, 100 controls will be recruited, with 50 from both centres.This study is a prospective clinical observational study with detailed data collecting. All patients will be treated according to the accepted, standardized, existing guidelines that are based on national and international recommendations. New treatment interventions will NOT be evaluated during the data acquisition for this study.
Status | Completed |
Enrollment | 396 |
Est. completion date | July 2014 |
Est. primary completion date | April 2014 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Severe or moderate brain trauma subjects with need of ICU care: - Glasgow Coma Score (GCS) = 8 after the primary stabilization has been performed in the field (= patient not hypoxic or hypotensive) and at least 30 min interval from the moment of injury. - GCS 9 - 13 and the patient is deteriorating - The patient has GCS = 13 and has other injuries, which require interventions for hemodynamic or ventilatory incidents - The patient is in urgent need of neurosurgery (craniotomy, impression skull fracture, severe haemorrhagic contusion, or ICP measurement) Moderate or mild brain trauma not in need of ICU care: - All other patients who fulfil the diagnostic criteria for an acute TBI but without any exclusion criteria defined below Exclusion Criteria: - Age < 18 years at study entry - Blast-induced TBI - Perforating or penetrating mechanism of TBI - Unable to live independently because of a brain disease (= e.g. people with moderate dementia, Down's syndrome, cerebral palsy etc.) or other medical cause before the injury - TBIs or suspected TBIs not needing cranial CT imaging (excludes the mildest TBIs with negligible risk for incomplete recovery) Inclusion criteria for control subjects - Age = 18 years at study entry - Acute orthopaedic non-trivial trauma that needs either surgery or conservative measures and clinical follow-up (including mere superficial soft tissue injuries) Exclusion criteria for control subjects - Age < 18 years at study entry - Loss of consciousness or amnesia or neurological symptoms or signs in conjunction with the injury, or suspicion of such - External injuries of the head caused by the acute injury - Acute injury of the spinal column and/or cord (including whiplash-injuries of the neck) - superficial soft tissue injuries without neurological symptoms or signs are not an exclusion - Any earlier TBI with loss of consciousness, amnesia or prolonged symptoms (days or more) - Suspicion or signs of TBI (recent or remote) in brain MRI - Trauma that needs care or observation at ICU, at any time point during the acute hospital period - Previous neurological illnesses with obvious permanent alteration in CNS function (cerebral palsy, multiple sclerosis, stroke, encephalitis, degenerative CNS disorders, etc.) |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Finland | Turku University Hospital | Turku | |
United Kingdom | Cambridge Addenbrooke's Hospital | Cambridge |
Lead Sponsor | Collaborator |
---|---|
Turku University Hospital | Cambridge University Hospitals NHS Foundation Trust, GE Healthcare, Imperial College London, Kaunas University of Technology, VTT Technical Research Centre of Finland |
Finland, United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Glasgow Outcome Scale -extended | •General outcome is assessed using the Glasgow Outcome Scale, extended version (GOS-E) | Time for outcome assessment is nine months (range 3 to 12 months) from the injury. | No |
Secondary | QOLIBRI | •The quality of life is assessed using QOLIBRI | 3 - 12 months from injury | No |
Secondary | CANTAB | •Cognitive outcome is assessed using CANTAB, an electronic test battery to evaluate neuropsychological function. The subtests used include tests of visual memory, executive function, working memory, planning, attention, semantic/verbal memory, decision-making, and response control | 3 - 12 months from injury | No |
Secondary | Rivermead Post Concussion Symptom Questionnaire | •Subjective outcome is assessed using the Rivermead Post-Concussion Symptom Questionnaire (RPCSQ) | 3 - 12 months from injury | No |
Secondary | SF-36 | •Subjective outcome is assessed using the SF-36 questionnaire | 3 - 12 months from injury | No |
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