Traumatic Brain Injury Clinical Trial
Official title:
The Neuromarker S-100B in Patients With Subarachnoidal, Epidural, Subdural, and Intracerebral Hematoma, Edema Cerebri, and Concussion
Abstract:
The most widely studied neuro-markers in traumatic brain injury (TBI) are S100B and neurone
specific enolase (NSE). S-100B is localized in astroglia. This marker is used to predict
neuronal damage caused by traumatic brain injury. The investigators conduct a study to
derive and validate the measurement of S-100B in serum of patients with different types
traumatic brain injuries.
The neuromarker S-100B is a well established tool for decision making in patients traumatic
brain injury (TBI)in Europe. In many hospitals S-100B is used routinely as a part of a set
of high- and medium risk factors aiding the decision to perform a cranial computed
tomography (CCT) in patients with minor head injury (MHI). In patients with severe head
injury Raabe et al. found a significant correlation between the S-100B levels and
unfavourable outcome in patients with severe brain injury with serum levels higher than 0.50
μg/l measured 24h after injury. The average level of the neuromarker, compared with other
studies. The study of Biberthaler et al. showed highest levels in patients with epidural
hematomas, followed by subdural, subarachnoidal and intracerebral hematomas. On the contrary
the average S-100B levels of patients with epidural hematomas featured in a study by Unden
et al. published in 2005 displayed normal levels (<0.2 μg/L). They concluded that S-100B was
unreliable as a marker for epidural hematomas.
Aim of the study Validation of S-100B in patients with intracerebral, epidural, subdural,
and subarachnoidal hematoma, brain edema and concussion (Group 1-6), to find evidence which
kind of injury leads to which level of elevation of the neuromarker measured in peripheral
blood.
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