Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI

Traumatic Brain Injury (TBI) Clinical Trial

— VAT  

Official title:

Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01750268
• Other study ID #: W81XWH-11-2-0145
• Status: Completed
• Phase: Phase 4
• Start date: November 2012
• Est. completion date: October 2015

Study information

• Verified date: September 2020
• Source: University of California, San Francisco
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of the proposed project is to improve the treatment of veterans with co-occurring traumatic brain injury (TBI) and hazardous or harmful alcohol use. The PI and coinvestigators will conduct a pilot controlled clinical trial of topiramate for the treatment of these co-occurring disorders.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 32
• Est. completion date: October 2015
• Est. primary completion date: October 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria

1. Male and female veterans.

2. Ages 18 to 65 (inclusive).

3. TBI: a history of mild traumatic brain injury, as defined by American Congress of Rehabilitation Medicine (ACRM) and VA, in the chronic, stable phase of recovery (>6 months from injury). The ACRM defines mild TBI as a traumatically-induced physiological disruption of brain function as demonstrated by at least one of the following:

3.a. loss of consciousness of up to 30 minutes;

3.b. any loss of memory for events immediately before or after the event;

3.c. any alteration in mental state at the time of the event, for example feeling dazed, disoriented, or confused; and

3.d. a focal neurological deficit or deficits that may or may not have been transient, for example loss of coordination, speech difficulties, or double vision. ACRM's definition further specifies that a person may be designated as having a mild TBI only if the severity of the injury does not include a loss of consciousness that lasted longer than 30 minutes, and post-traumatic amnesia lasting longer than 24 hours.

Rationale:

1. This is the most common description of patients currently served by our VA facilities.

2. Studies at this stable phase will facilitate detection of otherwise subtle changes as findings are less likely to be confounded by 'spontaneous' recovery.

4. Current (past month) hazardous alcohol use or harmful alcohol use.

4.a. Hazardous use is drinking that must meet criteria for "at-risk" or "heavy" drinking by National Institute on Alcohol Abuse and Alcoholism (NIAAA) criteria: Subjects must report current (past 30 day) "at-risk" or "heavy" drinking on an average weekly basis, consisting of an average of 15 or more standard drinks per week for men and 8 or more standard drinks per week for women during the 30 days prior to Screening Visit 1 as measured by the Alcohol Timeline Followback (TLFB) method.

4.b. Harmful use is drinking behavior that meets Diagnostic and Statistical Manual (DSM)-IV diagnostic criteria for an Alcohol Use Disorder (Alcohol Dependence or Alcohol Abuse).

5. Subjects must express a desire to reduce or stop alcohol use.

6. Female subjects must have a negative urine pregnancy test and must be either postmenopausal for at least 1 year or practicing an effective method of birth control (e.g., surgically sterile, spermicide with barrier, male partner sterilization; or absent and agrees to continue abstinence or to use an acceptable method of contraception, as listed above, should sexual activity commence).

7. Subjects must have a Breath Alcohol Concentration (BAC) of less than 0.02% when signing the informed consent form.

Exclusion Criteria

1. Psychotic disorders, bipolar disorders, dementia, or other psychiatric disorders judged to be unstable.

2. Subjects known to have clinically significant unstable medical conditions, including but not limited to: Clinically significant renal disease and/or impaired renal function as defined by clinically significant elevation of blood urea nitrogen (BUN) or creatinine or an estimated creatinine clearance of < 60 mL/min; AST and/or ALT > 5 times the upper limit of the normal range and/or a serum bilirubin > 2 times the upper limit of normal.

3. History of glaucoma.

4. History of kidney stones.

5. Concurrent participation in another alcohol treatment study or any study involving medications.

6. Female patients who are pregnant or lactating.

7. Topiramate use in the past week prior to study entry.

8. Use of medications for alcohol dependence (disulfiram, naltrexone, or acamprosate) within the past week.

9. Needing acute medical detoxification from alcohol based on a score of 12 or more on the Clinical Institute Withdrawal Assessment of Alcohol Scale (CIWA-AD).

10. Subjects who are legally mandated to participate in an alcohol treatment program.

11. Subjects who have had a suicide attempt in the past 6 months or suicidal ideation, with intent, in the 30 days prior to enrollment.

12. Subjects who have previously been treated with topiramate for any reason and discontinued treatment due to an adverse event or due to a hypersensitivity reaction to topiramate.

13. Subjects with seizure disorders.

14. Subjects currently being treated with another anticonvulsant.

15. Subjects who in the opinion of the investigator should not be enrolled in the study because of the precautions, warnings or contraindications outlined in the topiramate package insert.

Related Conditions & MeSH terms

• Alcohol Drinking
• Brain Injuries
• Brain Injuries, Traumatic
• Hazardous and Harmful Alcohol Use
• Traumatic Brain Injury (TBI)

Intervention

Behavioral:
• Medical Management Counseling
Brief alcohol and medication counseling

Drug:
• Topiramate
Experimental medication
• Placebo
Placebo comparator

Locations

Country	Name	City	State
United States	San Francisco VA Medical Center	San Francisco	California

Sponsors (4)

Lead Sponsor	Collaborator
University of California, San Francisco	Northern California Institute of Research and Education, San Francisco Veterans Affairs Medical Center, United States Department of Defense

Country where clinical trial is conducted

United States, 

References & Publications (1)

Pennington DL, Bielenberg J, Lasher B, Herbst E, Abrams G, Novakovic-Agopian T, Batki SL. A randomized pilot trial of topiramate for alcohol use disorder in veterans with traumatic brain injury: Effects on alcohol use, cognition, and post-concussive sympt — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Change in Alcohol Use as Assessed by the Timeline Followback (TLFB)	Using a calendar, participants provide retrospective estimates of daily drinking over a specified period.	Baseline to Week 12
Primary	Change in the Number of Drinking Days Per Week as Assessed by the Timeline Followback (TLFB)	Using a calendar, participants provide retrospective estimates of daily drinking over a specified period.	Baseline to Week 12
Secondary	Change in TBI Symptom Severity as Assessed by the Neurobehavioral Symptom Inventory (NSI)	Participants indicate the extent to which each of the 22 symptoms has disturbed them in the previous 2 weeks on a 5-item scale (0-none to 4-severe). The NSI total score is the sum of severity ratings of the symptoms. The scores are summed to yield a total score ranging from 0 to 88, where the higher the point value, the greater (more severe) the symptoms.	Baseline to Week 12