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Traumatic Brain Injury (TBI) clinical trials

View clinical trials related to Traumatic Brain Injury (TBI).

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NCT ID: NCT05675423 Not yet recruiting - Clinical trials for Traumatic Brain Injury (Tbi)

Imaging Characterization of the Biomechanical Coupling of Brain and Skull

Start date: June 26, 2024
Phase:
Study type: Observational

Background: Traumatic brain injury (TBI) affects over 1.7 million people in the United States each year. Many cases are mild, but people with a history of TBI may have long-term symptoms; they are also known to be more susceptible to future concussions. Researchers are working to understand how TBI affects tissues in and around the brain over the long term. This natural history study will investigate how a TBI may change the stiffness of the brain and its surrounding connective tissues. Objective: To see how the brain and connective tissues respond to small head movements in people with and without a prior TBI. Eligibility: People aged 21 to 65 years with a history of TBI. People with no history of TBI are also needed. Design: Participants will have 1 clinic visit that will last about 4 hours. Participants will have a physical exam. They answer questions to make sure it is safe for them to have a magnetic resonance imaging (MRI) scan of their brain. They will have an MRI scan in 2 parts. During the first part, participants will lie on a table that slides into a large tube. They will hear loud knocking noises. They may wear earplugs or earmuffs. They will lie still for 15 minutes at a time. They will be in the tube for about up to 75 minutes. The second part is called magnetic resonance elastography (MRE). Participants will lie with their head on a pillow that vibrates gently. This test will take 10 minutes. Participants will answer questions about how they feel 1 or 2 days after the procedure.

NCT ID: NCT05033444 Recruiting - Clinical trials for Traumatic Brain Injury (TBI)

A First in Human Study of the Safety, Tolerability and Pharmacokinetics of PRV-002 in Healthy Volunteers

Start date: September 17, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the safety, tolerability, and pharmacokinetics of different dose levels of PRV-002 in Health Volunteers

NCT ID: NCT04930146 Recruiting - Clinical trials for Traumatic Brain Injury (TBI)

Functional Recovery Effect of Bloodletting Puncture at Jing-well Points on Acute Brain Injury Patients

Start date: June 8, 2021
Phase: N/A
Study type: Interventional

Traumatic brain injury (Traumatic brain injury, TBI) can be derived from various forms of injury, including blunt trauma, penetrating or acceleration/deceleration force caused by head injury.There are some study data show that acupuncture treatment has a superficial effect on the prognosis of traumatic brain injury and can limit the progression of secondary brain injury, but the effect of early bloodletting at the Jing-points on TBI patients still unknown. In our study, the investigators have proposed a randomized, controlled study design and plan to evaluate the efficacy and safety of Jing-point puncture to improve consciousness and neurological function in patients with TBI. In addition, an objective meridian instrument analysis was added to analyze the energy distribution in the meridian of TBI patients.

NCT ID: NCT04796207 Completed - Clinical trials for Traumatic Brain Injury (TBI)

The Effects of Fish Oil Supplementation on the Brain Health of Collegiate Football Athletes

Start date: May 28, 2019
Phase: N/A
Study type: Interventional

Determine if the daily docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) supplement will reduce serum levels of biomarkers of sub-concussion injuries over a course of American football season among collegiate football athletes.

NCT ID: NCT04503473 Completed - Clinical trials for Traumatic Brain Injury (TBI)

Locomotor Recovery Following Traumatic Brain Injury

TBI_IU
Start date: August 1, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the effectiveness of two different walking training interventions on the recovery of strength, mobility, walking and other measures of health in individuals following traumatic brain injury. During this study, participants will aim to complete up to 15 training sessions over 4-5 weeks of each intervention with at least a 4 week break between interventions. Each training session will last approximately 1 hour, while testing sessions performed at the beginning and end of each intervention will last approximately 3-4 hours. Participation in this research study may last up to 6 months including screening and baseline testing. The possible benefits to participant from participation in this study include increased strength of the participants leg muscles and improved walking ability

NCT ID: NCT04003285 Not yet recruiting - Clinical trials for Traumatic Brain Injury (TBI)

Allopregnanolone in Chronic Complex Traumatic Brain Injury

ALLO
Start date: September 1, 2024
Phase: Phase 2
Study type: Interventional

This study will determine if allopregnanolone (ALLO) improves depression and pain symptoms in patients who have a history of mild traumatic brain injury (TBI) [primary endpoints]. The investigators will also determine if ALLO improves functional outcome [secondary endpoint]. Participants in this study will receive an intravenous infusion of either ALLO or placebo. Behavioral assessments will be conducted during the infusion and at several time points post-infusion.

NCT ID: NCT03874208 Recruiting - Clinical trials for Traumatic Brain Injury (TBI)

Prediction for Coma Recovery With Comaweb

COMASCORE
Start date: January 15, 2020
Phase: N/A
Study type: Interventional

The general objective of the comaScore project is to provide an external validation of the accuracy of the comaScore, a score derived from magnetic resonance imaging (MRI), to predict 1 year outcome of patients unresponsive to simple orders after traumatic brain injury (TBI), aneurysmal subarachnoid hemorrhages (aSAH) and cardiac arrest (CA) in the day 7 - day 45 period post brain injury.

NCT ID: NCT03314584 Completed - Clinical trials for Traumatic Brain Injury (TBI)

Managing MTBI-related Headaches With rTMS

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

Persistent headache is one of the most common debilitating symptoms in military personnel suffering from mild traumatic brain injury (MTBI). This study aims to assess the long-term effect of repetitive transcranial magnetic stimulation (rTMS) in managing MTBI related headaches for up to 2-3 months by comparing the treatment effect of active-rTMS to sham-rTMS.

NCT ID: NCT02918994 Active, not recruiting - Clinical trials for Traumatic Brain Injury (TBI)

LearningRx Cognitive Training for TBI

Start date: September 2016
Phase: N/A
Study type: Interventional

The purpose of this investigation is to conduct a series of case studies on the impact of LearningRx cognitive training on cognitive skills, brain structure, and daily functioning for participants with Traumatic Brain Injury (TBI).

NCT ID: NCT02878577 Completed - Clinical trials for Traumatic Brain Injury (TBI)

Monitoring the Alterations That Occur in the Brain Following Traumatic Brain Injury

TBI
Start date: September 21, 2016
Phase:
Study type: Observational

This project, will combine the data collected from existing and innovative technologies: fMRI scans, mapping brain connectivity using EEG in combination with eye-tracking technology (the BNA technology developed by ELMINDA), characterizing of cortical layers using magnetic resonance (the CoLI technology developed by Tel-Aviv University), and DTI imaging (imaging of brain tracks). To do so, Sheba's Medical Center, Tel Hashomer, joined the project and is responsible for recruiting patients from the Department of Neurosurgery and Department of Rehabilitation and also is responsible for performing the needed tests.