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Traumatic Brain Injury (TBI) clinical trials

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

View clinical trials related to Traumatic Brain Injury (TBI).

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Terminated
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NCT ID: NCT02504866 Terminated - Clinical trials for Traumatic Brain Injury (TBI)

Effect of Exercise Training on Physical, Cognitive, and Behavioral Function in People With TBI

Start date: December 15, 2016
Phase: N/A
Study type: Interventional

Background: - Traumatic brain injury (TBI) often causes problems with moving and balance, and thinking and emotions. Exercise can improve these things in people with other brain damage. Researchers want to look at the effect of exercise on these things in people with TBI. Objectives: - To study how head injuries affect the brain. To study if exercise can help some symptoms in people with TBI. These include problems thinking, balancing, and moving, and depression or anxiety. Eligibility: - People age between 18 and 79 - Had a non-penetrating TBI at least 12 months ago - Are physically inactive, but can stand and walk without help Design: - Participants will be screened with medical history, physical exam, and blood and urine tests. They may have a balance test. - Participants will be assigned to a high-intensity or a lower-intensity exercise program. - The study is 6 months long. There will be 3 months with exercise on an elliptical machine and 3 months without exercise. - Participants will exercise for 30 minutes on an elliptical machine, 3 days per week for 3 months. - Participants will also have 3 outpatient testing visits lasting approximately 8 hours, once every 3 months. This visit will include: - Blood tests - Tests for memory, attention, and thinking - Tests of walking and balance - Questionnaires - An MRI: they will lie in a machine that takes pictures of their brain, while breathing regular air and air with more carbon dioxide - Test of physical fitness