Trauma Clinical Trial
Official title:
Evaluation of Resuscitation Markers in Trauma Patients
Severe trauma patients have an elevated risk of multiple organ failure and death. In order to
increase survival possibilities the initial treatment must be focused into resuscitation from
shock. Traditionally the most common resuscitation markers used are vital signs and urine
output. Unfortunately, many patients might present normal vital signs, but still undergo a
compensated shock with persistent acidosis, hence being able to develop multiple organ
failure and death. Consequently, it is important to define better resuscitation markers for
these patients.
This investigation project consists in an observational prospective study, performed by a
multidisciplinary team, in which different resuscitation markers are evaluated in severe
trauma patients. There will be a specific timing (1st, 8th and 24th hours from arrival)
evaluation of different markers: hemodynamic (vital signs, urine output, etc); analytical
(lactate, base excess, natriuretic atrial peptide); tissue perfusion markers (NIRS);
microcirculation markers (videomicroscopy) and coagulopathy markers (thromboelastometry).
There will be a registry of total volume administration; blood cell transfusions and
vasoactive drug requirements. Each marker will be evaluated in relation to mortality;
multiple organ failure; massive transfusion protocol activation; blood cell transfusion
requirement; surgical control of bleeding requirement and emergent arteriographic
embolization. The objective of this study is to demonstrate which of these markers is better
to predict hemodynamic evolution of severe trauma patients and might become a guide for
resuscitation in the future.
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