Cardiovascular Diseases Clinical Trial
Official title:
Circulating Endothelial Cell and Endothelial Progenitor Cell Evaluation of Kidney Transplant Patients
We believe that certain cells in the human body (Circulating Endothelial Cells and Endothelial Progenitor Cells) are related to risk of cardiovascular disease. It may be possible to measure levels of these cells in patients who have had a kidney transplant and predict their risk of developing cardiovascular disease.
Coronary disease is one of the most common causes of morbidity and mortality in patients
with known chronic renal insufficiency and those with end stage renal disease. Consequently,
early detection with markers such as circulating endothelial cells and endothelial
progenitor cells has been studied in order to identify vascular function and assess overall
cardiovascular risk. Based on current research, there exists a notable increase in
Circulating Endothelial Cells (CEC) and a reduction of Endothelial Progenitor Cells (EPC)
with renal dysfunction due to endothelial damage. Therefore circulating endothelial cells
are a marker for cardiovascular health.
Renal transplant patients also possess a higher cardiovascular risk than the general
population, but have known improvement in survival as compared to patients with ESRD (End
Stage Renal Disease). In addition, because of the excellent outcomes, graft and patient
survival and even acute rejection are no longer very useful endpoints for clinical studies.
The tolerability of transplant drug regimens and the impact of these regimes on
cardiovascular health in kidney transplantation has become, consequently, a new focus of
research. Currently, no clear long-term analysis has been fulfilled analyzing CEC or EPC in
this group of patients. We hypothesize that CEC can serve as biological markers for
cardiovascular risk assessment in cadaveric and living renal transplant patients. We
eventually hope measurement of these cells can serve as an endpoint in determining
cardiovascular outcome in renal transplant patients. Our present study is aimed to get an
initial assessment of the kinetics of CEC and EPC in renal transplant recipients just prior
to transplant and for the first two years post transplant.
;
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05650307 -
CV Imaging of Metabolic Interventions
|
||
| Recruiting |
NCT05654272 -
Development of CIRC Technologies
|
||
| Recruiting |
NCT04515303 -
Digital Intervention Participation in DASH
|
||
| Completed |
NCT04056208 -
Pistachios Blood Sugar Control, Heart and Gut Health
|
Phase 2 | |
| Recruiting |
NCT04417387 -
The Genetics and Vascular Health Check Study (GENVASC) Aims to Help Determine Whether Gathering Genetic Information Can Improve the Prediction of Risk of Coronary Artery Disease (CAD)
|
||
| Not yet recruiting |
NCT06211361 -
Cardiac Rehabilitation Program in Patients With Cardiovascular Disease
|
N/A | |
| Not yet recruiting |
NCT06032572 -
Evaluation of the Safety and Effectiveness of the VRS100 System in PCI (ESSENCE)
|
N/A | |
| Recruiting |
NCT04514445 -
The BRAVE Study- The Identification of Genetic Variants Associated With Bicuspid Aortic Valve Using a Combination of Case-control and Family-based Approaches.
|
||
| Enrolling by invitation |
NCT04253054 -
Chinese Multi-provincial Cohort Study-Beijing Project
|
||
| Completed |
NCT03273972 -
INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers
|
N/A | |
| Completed |
NCT03680638 -
The Effect of Antioxidants on Skin Blood Flow During Local Heating
|
Phase 1 | |
| Recruiting |
NCT04843891 -
Evaluation of PET Probe [64]Cu-Macrin in Cardiovascular Disease, Cancer and Sarcoidosis.
|
Phase 1 | |
| Completed |
NCT04083846 -
Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of High-dose CKD-385 in Healthy Volunteers(Fed)
|
Phase 1 | |
| Completed |
NCT04083872 -
Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of Highdose CKD-385 in Healthy Volunteers(Fasting)
|
Phase 1 | |
| Completed |
NCT03466333 -
Postnatal Enalapril to Improve Cardiovascular fUnction Following Preterm Pre-eclampsia
|
Phase 2 | |
| Completed |
NCT03619148 -
The Incidence of Respiratory Symptoms Associated With the Use of HFNO
|
N/A | |
| Completed |
NCT03693365 -
Fluid Responsiveness Tested by the Effective Pulmonary Blood Flow During a Positive End-expiratory Trial
|
||
| Completed |
NCT04082585 -
Total Health Improvement Program Research Project
|
||
| Completed |
NCT05132998 -
Impact of a Comprehensive Cardiac Rehabilitation Program Framework Among High Cardiovascular Risk Cancer Survivors
|
N/A | |
| Completed |
NCT05067114 -
Solutions for Atrial Fibrillation Edvocacy (SAFE)
|