Transplantation Infection Clinical Trial
— TxL-FNOfficial title:
Renal Sensing of the Acidifying Effect of Sulphur-containing Amino Acids: Consequences for the Relation Between Protein Intake and Blood Pressure in Renal Transplant Recipients
Verified date | August 2017 |
Source | University Medical Center Groningen |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
Short-term (1-year) results of renal transplantation are now excellent (over 95%). Long-term (10-year and longer) results are, however, still disappointing. Where most research has focused on immunosuppression and infections, the investigators hypothesize that due to poor homeostatic capacity and necessary use of immunosuppressive and other drugs, renal transplant recipients are much more susceptible to poor dietary habits and exposure to potentially toxic contaminants than people of the general population, and that this contributes to accelerated function loss of the graft and excess risk of premature mortality, both contributing to poor long-term results. This study is a biobank and cohort study which investigates this hypothesis.
Status | Active, not recruiting |
Enrollment | 1007 |
Est. completion date | November 2028 |
Est. primary completion date | May 2011 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: More than one year after transplantation, prognosis > 1 year, stable
outpatients situation - Exclusion Criteria: Acute illnesses, fever, current hospitalisation |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
University Medical Center Groningen |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Change in renal function | Change in renal function over time | 20 years | |
Other | New Onset Diabetes After Transplantation | New Onset Diabetes | 20 years | |
Primary | Graft failure | Return to dialysis or re-transplantation | 20 years | |
Primary | All-cause mortality | Death | 20 years | |
Secondary | Cardiovascular mortality | Cause specific mortality | 20 years | |
Secondary | Cancer mortality | Cause specific mortality | 20 years | |
Secondary | Infectious disease mortality | Cause specific mortality | 20 years |
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