Androgen Effects on the Reproductive Neuroendocrine Axis

Status Not yet recruiting

Clinical Trial Summary

This research study investigates whether male-level exogenous androgens inhibit the reproductive neuroendocrine axis in otherwise healthy (non-PCOS) females.

Clinical Trial Description

Testosterone Replacement Therapy (TRT) is the mainstay of gender affirming care for transgender men (TGM) who have male gender identity after female sex assignment at birth. TGM receiving TRT over time exhibit irregular menstrual bleeding, however, the mechanism of menstrual disruption is unknown. Therefore, the investigators propose to evaluate the effect of chronic testosterone (T) exposure on ovarian hormones and pituitary gonadotropin release that determines menstrual cyclicity. The investigators will conduct a detailed study of urinary and blood reproductive hormone secretion in TGM before and during TRT as well as in untreated cisgender female (CGF) control subjects who report female gender identity congruent with female sex assignment at birth. The investigators will also perform periodic clinical and ultrasonographic evaluations. Furthermore, the investigators will monitor menstrual cycles and reproductive hormones in TGM who make the personal decision to discontinue TRT, whether it is to pursue fertility or for other reasons. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06450405
Study type	Observational
Source	University of California, San Diego
Contact	Antoni Duleba, MD
Phone	619-804-4765
Email	aduleba@health.ucsd.edu
Status	Not yet recruiting
Phase
Start date	June 1, 2024
Completion date	June 1, 2029

View Details

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