View clinical trials related to Transgender.
Filter by:Will use a subset of the main study cohort of transgender or non-binary individuals to evaluate the relationships between self-reported exogenous hormone use, endogenous hormone values, renal biomarkers, drug levels and directly measured renal function.
Prospective observational study and biobank in all persons referred to CKIO - Patient involvement and quality of life - Population characteristics regarding hormone levels, safety parameters and clinical outcome before and after gender affirming hormone treatment.
Aim 1 utilizes prospective clinical studies in TGN to test the hypothesis that prolonged exogenous androgens alter menstrual cyclicity by inhibiting gonadotropin secretion, steroid hormone release, and ovulation. We will utilize a clinical trial of TRT to evaluate T suppression of ovarian follicle and hormone dynamics (Aim 1A) and LH pulsatility (Aim 1B).
Despite increased visibility and acceptance of the LGBT community (Lesbian, Gay, Bisexual and Transgender), in some parts of society, many LGBT people struggle with self-acceptance. Minority Stress Theory, described in the scientific literature, explains that health disparities among populations such as the LGBT population can be explained by stressors induced by a hostile, homophobic culture, which results in harm suffered, expectations of rejection, and internalized homophobia. The harm suffered may include acts of discrimination, harassment, violence (physical or linguistic). But more deeply, two important points of this theory: 1) the expectations of the LGBT person to experience rejection based on their identity and the anti-LGBT social stigma, 2) internalized homophobia, which is a social internalization from negativity against homosexuality and transgender to the initial stages of the identity development of an individual who can continue throughout his life. Perceived harm, stigma and lived rejection are associated with an increased propensity to experience significant psychological pain. LGBT people are more likely to develop self-identification based on sexual orientation or gender, making them more vulnerable to any rejection signal. There is a growing scientific interest around Cognitive and Behavioral Therapies (CBT) of 3rd wave, also called therapies derived from Buddhism, or therapies based on meditation. These programs aim to observe and test, through an experiential meta-cognitive practice, the dogmas or preconceptions (about ourselves, others, and the world) and mental attitudes that guide our choices without our knowledge and are at the origin of suffering, in order to gain inner freedom. These practices constitute an experiential scientific methodology of self-knowledge and reality. These secular programs have become a standard treatment in the management of stress, chronic pain, and the prevention of relapsing depression. In addition, the interest of these practices has been demonstrated in many areas of somatic and psychiatric medicine (including depression and suicidal behavior), but also for the promotion of mental health in the general population. This topic is the subject of more than 15,000 international scientific publications with reading committee (Medline indexed), and of strong interest and shared by both the scientific community and the general public. Scientists are currently deepening these therapies with a focus on wisdom-based self-identification. Beyond the name "therapies", this educational information is key to life for everyone. Who am I ? Am I defined by my social roles, my physical characteristics, my preferences? How to face external challenges? How to develop real self-confidence? Dr Déborah Ducasse offers a conference on the theme: "Sexual orientation, gender: where is the problem?" Nowhere. Self-identification. ". This conference will take place on 05/15/2020, on the occasion of World Day Against Homophobia. In line with the OECD press release in 2019 "The LGBT challenge: how to improve the integration of sexual and gender minorities? "(Panorama de la société 2019: Social Indicators of the OECD), the investigators want to assess whether an intervention targeting valid self-identification can 1) have a positive impact on the acceptance and discrimination indicators of the OECD ; 2) have an impact on valid self-identification. Direct benefits are expected, psychologically and socially, in the fight against discrimination, inclusion and self-acceptance. In the medium and long term: major public health interest via the adaptation of psychoeducational interventions based on self-identification in order to prevent psychosocial risks and suicidal behavior in connection with an altered self-identification based on sexual orientation and gender.
This study will examine markers of vascular endothelial function (vascular health) and metabolic profiles in older versus younger transgender men (people who were assigned female at birth but whose gender identity is male). Data will also be compared to those from age group-matched transgender women and cisgender women and men.
This study will examine markers of vascular endothelial function (vascular health) and metabolic profiles in younger versus older transgender women (people who were assigned male at birth but whose gender identity is female). Data will also be compared to those from cisgender women and men.