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Transfusion Reaction clinical trials

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NCT ID: NCT03182491 Active, not recruiting - Allergy Clinical Trials

Mechanisms of Anaphylaxis

ANAMEK
Start date: April 28, 2017
Phase:
Study type: Observational [Patient Registry]

The purpose of this study is to explore different mechanisms for anaphylaxis and find novel biomarkers for this hypersensitivity syndrome. The study participants are patients with anaphylaxis, patients with mild allergic reactions, and patients with febrile transfusion reactions. The investigators will also include a group of healthy controls.

NCT ID: NCT03146455 Completed - Coagulopathy Clinical Trials

Thromboelastography Normal Reference Values in China Hunan Province

Start date: June 5, 2017
Phase:
Study type: Observational

The purpose of this study was to establish the normal reference range of Thrombelastogram parameters in Hunan by a multicenter study, and to analyze the specificity of Thrombelastogram detection and the influence of gender, age and blood type on Thrombelastogram. The study will provide basic data and statistical basis for the establishment of normal reference range of Thrombelastogram in Hunan.

NCT ID: NCT03135457 Completed - Clinical trials for Transfusion-associated Circulatory Overload

TACO Crossover TRIAL

Start date: August 16, 2017
Phase: N/A
Study type: Interventional

This is an open-label, prospective crossover randomized controlled trial to investigate wether TACO is solely hydrostatic pressure overload or arises from a combination of hydrostatic pressure overload and capillary leakage, by investigating the difference in change in static pressure parameters (PCWP), dynamic volume parameters (PICCO) as indirect measurements of volume status and capillary leakage after autologous transfusion or saline infusion. The investigators will estimate effective circulating volume following autologous transfusion or saline infusion. Furthermore, the investigators will investigate the effect of fluid loading on the microcirculation.

NCT ID: NCT03056378 Withdrawn - Anemia Clinical Trials

POOLED Red Blood Cells Prepared From Pooling 5 Leukoreduced, Irradiated RBC Units

Pooled RBCs
Start date: October 2019
Phase: Phase 1
Study type: Interventional

The purpose of the study is to determine the safety of pooled red blood cells (RBCs) compared to standard leukoreduced RBC products stored in additive solution. The primary objective is to determine if there is no significant difference in transfusion associated adverse events in POOLED-RBCs compared to standard RBC product groups. Secondarily to determine if there are no significant differences in new antibody and new positive direct antiglobulin test (DAT) formation in the POOLED-RBCs compared to standard RBC product groups.

NCT ID: NCT03037164 Recruiting - Anemia Clinical Trials

INTERCEPT Blood System for RBCs Study in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections

RedeS
Start date: May 11, 2017
Phase: Phase 3
Study type: Interventional

Stage A: To evaluate the safety and efficacy of red blood cells (RBCs) prepared with the INTERCEPT Blood System for Red Blood Cells Pathogen Reduction Treatment (PRT) in comparison to conventional RBCs in patients who require RBC transfusion support. Stage B: To provide early access to the INTERCEPT pathogen reduction system for RBC in regions where a substantial proportion of the population has been infected or is at risk of a transfusion-transmissible infection. The objectives and design of Stage B will be reassessed on the completion of Stage A, in consultation with the FDA.

NCT ID: NCT02841111 Completed - Clinical trials for Disorder Related to Renal Transplantation

Old Red Blood Cell In Renal Transplantation

ORBIT
Start date: January 2002
Phase: N/A
Study type: Observational

Kidney transplantation is the treatment of choice for ESRD. However, the life expectancy of kidney transplant patients is lower than that of the general population. Deaths recipients are due mainly to cardiovascular diseases related to a chronic inflammatory state. In addition, renal transplant patients frequently have anemia, identified as an independent cardiovascular risk factor that can be corrected by blood transfusion. But the relationship between transfusion and inflammatory condition are bidirectional. The patient's inflammatory condition will sound on the effectiveness of transfusion and transfusion could trigger an inflammatory condition. This has been reported with the said blood components "aged", especially with packed red cells in patients hospitalized in intensive care after heavy heart surgery.The main objective of this study is to evaluate the impact of early transfusions on the evolution of renal transplantation (ie death, anti-HLA immunization, acute rejection, graft loss, delayed graft function, cardiovascular events ) taking into account in the analysis: patient age at the time of transplantation, the number of incompatibility (s) (HLA class I and / or II) between the graft and the patient and sex of the recipient. This is a multicenter retrospective observational study (descriptive epidemiological study).The impact of early transfusions is determined retrospectively over a period of 6 years from 01 January 2002 to 31 December 2008, in renal transplant patients of all centers of France met the criteria for inclusion. This cohort represents about 12 000-14 000 patients

NCT ID: NCT02607150 Completed - Clinical trials for Idiopathic Scoliosis

Changes in Cerebral Oxygenation During the Administration of Cell Saver Blood and Allogeneic Blood

Start date: December 2014
Phase: N/A
Study type: Observational

A prospective study designed to evaluate changes in tissue and cerebral oxygenation before and following administration of blood for patients undergoing spinal surgery. Red blood transfusions (autologous and allogeneic) are indicated to improve oxygen delivery to the tissues and hence tissue oxygenation. Despite the presumed efficacy, there are limited data to demonstrate changes in tissue oxygenation with the administration of blood. Furthermore, the administration of both autologous blood from cell saver and allogeneic blood can be associated with both acute and long-term deleterious physiologic effects which may impact the perioperative course. As such, data are needed to clearly delineate the benefits of transfusion during the perioperative period.

NCT ID: NCT02423135 Completed - Clinical trials for Transfusion Reaction

Detection of Autologous DEHP (DiEthylHexyl Phthalate)-Free Blood Transfusion in Anti-doping

Start date: October 2014
Phase: N/A
Study type: Interventional

The aim of the proposed project is to perform a clinical study in which volunteers will receive autologous blood transfusions in DEHP-free blood bags.

NCT ID: NCT02200692 Completed - Allergy Clinical Trials

Allergic Transfusion Reactions in Plasma Transfusion

Start date: June 2014
Phase:
Study type: Observational

Allergic transfusion reactions are a common complication of transfusion by blood components containing plasma. This study aims to investigate passive transfer of Immunoglobin E antibodies as a risk factor of allergic reactions to plasma transfusion by use of Solvent Detergent plasma.

NCT ID: NCT02094118 Completed - Clinical trials for Blood Transfusion Complications

Point-of-Care RBC Washing to Prevent Transfusion-Related Pulmonary Complications

Start date: January 2016
Phase: Phase 1/Phase 2
Study type: Interventional

This study is designed to determine if point-of-care washing of allogeneic Leukocyte-Reduced Red Blood Cells reduces pulmonary complications when compared to standard-of-care Leukocyte-Reduced Red Blood Cells in a cardiac surgical population.