Transformed Waldenström Macroglobulineamia Clinical Trial
Official title:
Transformed Waldenström Macroglobulinaemia: Clinical Presentation and Outcome. A Multi-institutional Retrospective Study of 77 Cases From the French Innovative Leukemia Organization (FILO)
Histological transformation to diffuse large B-cell lymphoma is a rare complication which may occur in Waldenstrom macroglobulinemia. In this multicenter study, we retrospectively analyzed the clinico-biological features, therapy, outcomes and prognostic factors in 77 Waldenstrom macroglobulinemia patients with biopsy-proven transformation to diffuse large B-cell lymphoma.
Histological transformation to diffuse large B-cell lymphoma is a rare complication which may
occur in Waldenstrom macroglobulinemia. In this multicenter study, we retrospectively
analyzed the clinico-biological features, therapy, outcomes and prognostic factors in 77
Waldenstrom macroglobulinemia (WM) patients with biopsy-proven transformation to diffuse
large B-cell lymphoma (DLBCL).
We retrospectively searched the databases of French and Belgian centers for patients older
than 18 years diagnosed with WM and a concurrent or sequential diagnosis of DLBCL between
1995 and 2016. Nineteen centers belonging to the French Innovative Leukemia Organization
(FILO) group participated in this study. Patients with a diagnosis of indolent lymphoma other
than WM were excluded. The diagnosis of WM was based on criteria established in the Second
International Workshop on WM. Clinical, biological data and prognostic scores were recorded.
Quantitative variables were expressed as median and range and qualitative variables as number
and percentages. Multivariate analyses using cox proportional hazard model were conducted to
investigate the factors independently related to progression-free survival and overall
survival.
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