Cardiovascular Diseases Clinical Trial
Official title:
Evaluation of the Effect of 10% Lidocaine Spray on Hemodynamic Response and EKG Parameter Performed Before Endotracheal Intubation in Patients Undergoing Coronary Artery Bypass Graft Operation
In patients undergoing coronary bypass surgery; 10% topical lidocaine administered endotracheally before intubation is to investigate the effect of hemodynamic response and EKG paramater after intubation.
This prospective randomized double-blind study consisted of 60 volunteers undergoing coronary
artery bypass surgery. Patients will be randomized and divided into two groups as control
(Group C) = 30) and topical lidocaine group (Group L) = 30). Two intravenous 18-gauge (G)
cannula will be inserted to all patients. Premedication will be provided with 0.03 mg/kg
intravenous (iv) midazolam (Dormicum 1 mg/ml, Roche preparations Inc., Istanbul Turkey) and
50 mcg fentanyl and patients will be given 2 L / min O2 via nasal cannula. Radial artery
cannulation will be performed by applying an Allen Test with 20G cannula under topical
anesthesia. heart rate (HR), mean arterial pressure (MAB), peripheral oxygen saturation
(SpO2) will be recorded. Induction of group C will be performed after preoperative
preparation. No intervention will be made in group c and standard anesthesia protocol will be
applied.
Group L (intervention group) Oral-tracheal lidocaine spray will be applied. The induction of
group L will be performed 5 minutes after administration of 10% topical lidocaine (Lidocaine
pump spray 10% 50 ml) 160 mg (16 puffs) . After pre-oxygenation, anesthesia induction will be
performed with intravenous administration of 2 μg / kg fentanyl, 2 mg/kg propofol, 0.6 mg/kg
rocuronium bromide (Esmeron 5 mg vial, Organon Oss Holanda). Tracheal intubation of all
patients will be performed by an experienced anesthesiologist after providing adequate
relaxation. Anesthesia will be maintained with sevoflurane(Forane, Abbott, İstanbul Türkiye)
% 2 in a 50% Air +50% O2 mixture. ECG recording of participants will be performed before
(baseline) and after one minute from induction and at the first and third minutes following
intubation. Hemodynamic measurements and record (MAB, HR, SpO2) will be performed at baseline
one minute after the induction of anesthesia as well as at 1,3,5,10 min after tracheal
intubation. Before the ECG analysis, all participants will be blinded by closing their group
names on the ECG recording. QTc (corrected QT,), QT intarvale dispersion (QTd), P wave
dispersion will calculated by a blind researcher within a 12-lead ECG recording (velocity: 25
mm / sec, Amplitude: 10 mm / mV). QTd , was the difference between the longest QT
intervale(QT max.) durations and shortest QT intervale(QT min.) durations(msec); P wave
dispersion, was the difference between the longest and shortest P-wave durations(msec); QTc
interval was calculated using Bazett's formula (QTc = QT/√RR).)
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