Schizophrenia Clinical Trial
Official title:
Pilot Trial of Valproate as Adjunctive Treatment for Toxoplasma Gondii
This is an exploratory study in Egypt that will combine a treatment trial among early course
schizophrenia (ECSZ) patients with key analyses suggested by rodent studies. Specifically,
the study will test the provocative results from animal studies indicating an impact of
Toxoplasma Gondii (TOX) exposure on novelty seeking. The study will also test whether
exposure to TOX is associated with other cognitive and behavioral changes, as well as changes
in overall social function. We will also explore the relative efficacy of Sodium Valproate
(Depakote, DEP) in improving clinical and overall social function among TOX exposed and
unexposed patients.
Hypotheses
1. At baseline, TOX exposure is associated with increased novelty seeking, clinical
severity, and impaired cognitive and overall social function in patients with SZ.
2. Adjunctive DEP treatment improves clinical symptoms, cognitive and social function in
SZ, particularly among TOX exposed SZ patients.
3. Exploratory hypothesis: adjunctive DEP reduces serological indices of TOX infection (VIP
and TH levels).
n/a
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