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NCT03628703 Clinical Trial

Response Inhibition in Tourette Syndrome

Tourette Syndrome Clinical Trial

Official title:
Using Repetitive Transcranial Magnetic Stimulation to Modulate Response Inhibition in Tourette Syndrome

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03628703
Other study ID # CIN001 - TAA2018
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date April 22, 2019
Est. completion date March 15, 2024

Study information
Verified date April 2024
Source Children's Hospital Medical Center, Cincinnati
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Tics are the hallmark symptoms in Tourette Syndrome. Patients with Tourette Syndrome have difficulties controlling unwanted movements. The ability to control the motor system involves the pre-supplementary motor area (pre-SMA) in the brain. In this study, we will use Transcranial Magnetic Stimulation to modulate the pre-SMA and determine effect on the ability to stop an unwanted action in a behavior task (stop signal task).

Recruitment information / eligibility
Status Completed
Enrollment 10
Est. completion date March 15, 2024
Est. primary completion date June 30, 2023
Accepts healthy volunteers No
Gender All
Age group 10 Years to 17 Years
Eligibility Inclusion Criteria: - Tourette Syndrome Exclusion Criteria: - Autism spectrum disorder - Mood disorder - Epilepsy - Implanted medical device (e.g. pacemaker, shunt, pumps)

Study Design

Related Conditions & MeSH terms

Intervention

Device:
• Repetitive TMS
Repetitive Intermittent Theta-Burst Transcranial Magnetic Stimulation over the right Pre-supplementary Motor Area

Locations
Country Name City State
United States Cincinnati Children's Hospital Medical Center Cincinnati Ohio

Sponsors (1)
Lead Sponsor Collaborator
Children's Hospital Medical Center, Cincinnati

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Stop Signal Reaction Time (SSRT) SSRT measured from modified Slater-Hammel stop signal task performance. The SSRT is calculated by subtracting the average stop signal delay (msec) from the average go-trial reaction time. The SSRT is a measure of inhibitory behavior. The lower the SSRT value means a person is better at inhibitory control. The higher the SSRT value means a person is worse at inhibitory control. 30 minutes after Repetitive Transcranial Magnetic Stimulation (as it takes about 30 minutes to complete the modified Slater-Hammel stop signal task)
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