Tourette Syndrome Clinical Trial
Official title:
Scheduled and Responsive Brain Stimulation for the Treatment of Tourette Syndrome
The purpose of this trial is to determine whether a particular type of Deep Brain Stimulation
(DBS), scheduled Deep Brain stimulation (SBS), is an effective and safe treatment for
Tourettte syndrome (TS).
The trial will also examine the brain activity associated with TS and tics and explore the
possibility of responsive brain stimulation (RBS).
DBS is a surgical procedure that seeks to change the brain's electrical signalling by means
of applied electrical current. To this end, a wire with tiny stimulating electrodes is
implanted into one or both sides of the brain. An electrode is a small piece of metal used to
take an electric current to or from a power source. These electrodes are connected under the
skin on the scalp to a small electrical unit called an INS (implantable neurostimulator),
which is similar to a heart pacemaker. The device sends out electrical impulses that appear
to change the normal flow of electricity in the brain.
The wires which house the electrodes will be implanted on both sides of the brain oriented
towards the centromedian thalamus-parafascicular complex. This region of the brain has to
date the greats number of documented cases revealing significant improvements in motor tics.
This region of the brain will also provide a target where physiological changes related to
motor tics are likely to be discovered.
The device we propose for this study has several features that make it more suitable for use
in the TS population than other devices. It is self-contained in the skull and brain, and
contains no tunneled neck connector wire and no chest pacemaker deice. This will help to
lessen infection, and will assist in limiting device-related fractures due to tics involving
neck region. Also, the system can record electro-encephalograph data from the area of the
electrodes, which will assist us in gathering information about what specific physiological
changes are correlated with tics.
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