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Clinical Trial Summary

This is a single site, pilot double-blind, randomized, placebo-controlled, cross-over study of 10 participants comparing medicinal cannabis (THC:CBD 10:15 oil) with placebo in reducing tics in adolescents aged 12 - 18 years with severe Tourette Syndrome (TS). The primary objective of this pilot study is to evaluate all elements of the study design (recruitment strategy, study duration, study procedures, study medication tolerance and outcome measures) to assess if they are acceptable and feasible for the conduct of a full-scale randomized controlled trial of THC:CBD 10:15 oil to reduce tic severity in adolescents with TS. The secondary objective of this study is to collect preliminary data on the safety of oral THC:CBD 10:15 oil in adolescents aged 12 to 18 years with TS. As an exploratory aim data from clinician- and parent-rated measures will be compared across the phases to explore for a signal of efficacy on primary (tic reduction) and secondary (premonitory urges, obsessive compulsive behaviors, Attention Deficit Hyperactivity Disorder [ADHD] symptoms) outcome measures.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05184478
Study type Interventional
Source Murdoch Childrens Research Institute
Contact Daryl Efron
Phone +61 (3) 8341 6200
Email [email protected]
Status Not yet recruiting
Phase Phase 1/Phase 2
Start date January 2022
Completion date June 2023

See also
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Not yet recruiting NCT05188274 - A Clinical Study to Evaluate the Safety and Efficacy of T92 in Pediatric Patients With Tourette Syndrome N/A
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Recruiting NCT04087616 - Internet-based CBIT for Children With Chronic Tics N/A
Recruiting NCT03765463 - Extinction Learning in Youth With Tourette Syndrome N/A
Not yet recruiting NCT04179435 - Cognitive and Brain Development in Adolescents With Gilles de la Tourette Syndrome N/A