Morphine Consumption in Joint Replacement Patients, With or Without Gabapentin Treatment

Post Operative Pain Clinical Trial

Official title: Multiple Doses of Gabapentin and Postoperative Morphine Consumption in Total Knee Arthroplasty

Status Completed

Clinical Trial Summary

Total knee arthroplasty is amongst the most painful procedures postoperatively, and pain management can be a challenge. Different measures have been introduced to manage severe postoperative pain int hese patients. Previous studies have investigated gabapentin in acute postoperative pain and demonstrated reducted pain, postoperative morphine consumption, morphine related side effects, and postoperative pain scores. To date, this analgesia adjunct has yet to be investigated in total joint arthroplasty patients.

Clinical Trial Description

The study was submitted to Health Canada and received the letter of no objection. A randomized, double-blind, placebo-controlled study. The randomization scheme will be prepared and will be done by the pharmacy department at McMaster University. Ninety patients undergoing primary knee arthroplasty will be recruited from the preoperative clinic. Forty-five patients in each population will be allocated to a gabapentin group and the other forty-five to a placebo group. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Pain, Postoperative
• Post Operative Pain
• Total Knee Replacement

• NCT number: NCT01307202
• Study type: Interventional
• Source: McMaster University
• Status: Completed
• Phase: N/A
• Start date: October 2007
• Completion date: February 2011