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Total Knee Replacement clinical trials

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NCT ID: NCT05541666 Recruiting - Clinical trials for Total Knee Replacement

The Effect of Emotional Freedom Technique on Postoperative Pain and Anxiety on Total Knee Replacement

Start date: March 7, 2022
Phase:
Study type: Observational

Since pain is a complex and unpleasant feeling that affects the individual physically, mentally and socially, it should be controlled. It is also known that major surgeries such as orthopedics and traumatology, general surgery and cardiovascular surgery cause fear of death in the patient, and this fear is then replaced by general anxiety and post-operative pain. The emotional freedom technique is a method that uses cognitive functions and physical components (tapping acupuncture points) to bring about psychological changes. It is also defined as "needle-free acupuncture" or "an emotional form of acupressure" because it is a gentle, non-invasive procedure and uses acupuncture meridians. This method, which is very old in Eastern cultures, started to be used in the West in the 1980s. In this developed technique, all 12 points on the 12 basic meridians, which are the flow paths of the energy in the body, are used. In the emotional liberation technique tour, general anxiety, phobias, post-traumatic stress disorder, fears and the discomfort caused by anxiety are eliminated and all kinds of targeted problems are cured. Considering the patients as a whole in terms of biopsychosocial is the basic element of nursing. It is inevitable to experience pain and anxiety in the post-operative period in individuals who are in a foreign environment such as a hospital and who have undergone major surgery such as total knee replacement. With this study, it is expected that the emotional freedom technique will contribute to the national and international literature on the effect of pain and anxiety in the post-operative period and will be a source of information in the development of nursing science on the use of non-pharmacological treatments that can be used in the treatment of pain and anxiety in patients.

NCT ID: NCT05439564 Completed - Clinical trials for Total Knee Replacement

Intrathecal Morphine Versus Morphine-dexmedetomidine Combination for Postoperative Pain Control After Total Knee Replacement

Start date: July 1, 2022
Phase: N/A
Study type: Interventional

Total knee replacement is one of the most painful orthopedic surgical procedures. Patients who undergo total knee replacement are usually older and have limited cardiac and pulmonary reserves. The increased sensitivity of elderly patients to drugs makes it necessary to choose postoperative analgesia agents and methods that have minimal side effects. Intrathecal injection of morphine to provide postoperative analgesia during the initial 24-h after the operation is a widely used technique, however, opioid therapy is limited because of the side effects (hypotension, pruritus, nausea, urinary retention, respiratory depression) and intolerance. Alpha-2 adrenergic agonists (clonidine and dexmedetomidine) have pharmacologic characteristics (sedation, hypnosis, anxiolysis, sympatholytic, and analgesia) that make them suitable as adjuvants to multimodal analgesia. Their anti-nociceptive effect is attributed to the stimulation of a2- adrenoceptors located in the central nervous system. The rationale for combining analgesics that produce similar therapeutic effects or synergistic interactions is to accentuate the analgesic efficacy and decrease the side effects by permitting dose reduction of each agent. Human studies on the antinociceptive effects of co-administrated intrathecal morphine (ITM) and dexmedetomidine in postoperative pain are still few. On the other hand, Abdel-Ghaffar et al., results do not support improved analgesia with the combination of intrathecal morphine and dexmedetomidine, despite the absence of significant adverse effects. We hypothesized that the addition of dexmedetomidine to ITM would improve the quality of perioperative pain control and decrease the side effects of postoperative systemic opioid use.

NCT ID: NCT05434767 Completed - Clinical trials for Total Knee Arthroplasty

Evaluating the Feasibility and Effectiveness of Using a Smartphone Application During Rehabilitation in Patients After Total Knee Replacement

Start date: June 29, 2022
Phase: N/A
Study type: Interventional

Despite best efforts to provide standardized and effective rehabilitation sessions post-total knee replacement (TKR), there are a few factors that may result in sub-optimal recovery in this group of patients. There is a need to develop innovative rehabilitation strategies that (i) provide patients with accurate cues allowing for better compliance and exercise performance, (ii) allow for therapists to ensure continuity of care, monitor compliance, and identify deviation from recovery trajectories post-discharge, prior to their first outpatient appointment, and (iii) reduce reliance on manpower and variability during rehabilitation sessions. Technological solutions that empower patients and allow home-based rehabilitation to take place without the need for real-time human supervision could be the key to improving effectiveness and lowering costs. A mobile application which detects key landmarks on the body for human pose estimation will allow patients to perform their rehabilitation exercises with real-time feedback allowing for proper execution of the exercises. Physiotherapists will be able to access the data generated from the exercise session via a command centre to monitor patients' recovery progress and compliance. The primary aim of this pilot study is to evaluate the feasibility of using a mobile application during rehabilitation in patients after a TKR surgery. The secondary aim is to study the effects of using a mobile application during rehabilitation on knee functional status, exercise self-efficacy, and treatment satisfaction after TKR surgery.

NCT ID: NCT05291598 Completed - Clinical trials for Total Knee Replacement

Meloxicam for Pain Management After Total Joint Arthroplasty (TJA)

Start date: May 1, 2022
Phase: Phase 3
Study type: Interventional

The purpose of this project is to determine if a change in patient reported pain, nausea and vomiting after total knee and hip arthroplasty could be observed with the substitution of Intravenous meloxicam for ketorolac in the current established peri-operative pain protocol and if these changes lead to a decrease in opioid consumption (in morphine equivalents).

NCT ID: NCT05279092 Recruiting - Clinical trials for Total Knee Replacement

Yale Steroid Enhanced Versus Exparel Nerveblock TKA RCT Study

Yale SEVEN
Start date: September 8, 2022
Phase: Phase 2
Study type: Interventional

The objective of this phase 2 study is to investigate the efficacy of Dexamethasone sodium phosphate (DEX) plus Methylprednisolone acetate (MPA) in combination with plain bupivacaine (B) compared with Liposomal Bupivacaine (LB) in combination with plain bupivacaine on post-surgical pain control among patients undergoing unilateral total knee arthroplasty (TKA) to asses if perineural B-DEX-MPA will result in superior analgesia efficacy as compared to B-LB. This study will also assess if perineural B-DEX-MPA results in improved quality of postoperative recovery as compared to B-LB.

NCT ID: NCT05263856 Not yet recruiting - Knee Osteoarthritis Clinical Trials

The Effect of Laser Acupuncture Intervention to the Prognosis After TKR Surgery

Start date: March 7, 2022
Phase: N/A
Study type: Interventional

This study protocol is mainly focus on the patients, who suffer pain, swelling, or range of motion limitation after total knee replacement (TKR) surgery procedure,would be relieved by use non-invasive laser acupuncture to stimuli on 1) the reflection areas of ear acupuncture point associated knee and pain mechanism; 2) muscle trigger points around knee joint with adequate frequency and energy power to stimuli.

NCT ID: NCT05211141 Active, not recruiting - Clinical trials for Total Knee Arthroplasty

Study to Evaluate Long Term Performance and Safety of the Knee Prosthesis (HLS KneeTec Deep Dish)

Start date: February 28, 2017
Phase:
Study type: Observational

The aim of this study is to assess the long-term performance and safety of HLS KneeTec Deep Dish knee prosthesis when used in standard medical practice

NCT ID: NCT05137028 Completed - Clinical trials for Total Knee Replacement

Otago Exercise in Patient With Total Knee Replacement

Start date: November 13, 2021
Phase: N/A
Study type: Interventional

To determine the effect of Otago exercise in Total Knee Replacement

NCT ID: NCT05115565 Not yet recruiting - Clinical trials for Total Knee Replacement

The Effects of Transcutaneous Electrical Nerve Stimulation in Patients With Total Knee Replacement

Start date: November 15, 2021
Phase: N/A
Study type: Interventional

Total Knee Replacement (TDP) is considered the best treatment option available when conservative methods such as anti-inflammatory or physical therapy fail. However, TDP surgeries are also a serious trauma that causes severe pain in patients. Uncontrollable pain exacerbates the stress response and causes morbidity and mortality by causing negative changes in the neuroendocrine, respiratory, cardiovascular, gastrointestinal, renal and immune systems. Therefore, the relief of pain has very important effects on the patient's recovery process, functional status and quality of life. Transcutaneous Electrical Nerve Stimulation (TENS) is one of the non-pharmacological methods for pain relief in TDP surgeries. This study was planned as a randomized controlled trial to examine the effects of TENS after TDP on acute pain, functionality and quality of life.

NCT ID: NCT05064943 Completed - Clinical trials for Total Knee Replacement

Reliability and Validity of the 2-Minute Step Test in Patients With Knee Arthroplasty

Start date: November 25, 2021
Phase:
Study type: Observational

Total knee arthroplasty (TKA) is a cost-effective treatment for end-stage knee osteoarthritis. It has demonstrable benefits such as reducing pain and improving activity and quality of life. Despite the decrease in pain after surgery, the expectations of patients regarding their physical functions are not fully realized. Physical performance tests and reporting tests are used to objectively evaluate physical function and reveal the patient's condition. It is known that physical performance tests better reflect post-surgical changes. In addition, it has been stated that there may be serious differences between the results of the reports based tests and the actual functional capacities of the patients. The 2-minute walk test and the 6-minute walk test are tests that are used in the evaluation of lower extremity physical performance and have been shown to be valid and reliable in different populations. However, a certain length of corridor is needed in order to carry out these timed walking tests. As an alternative to these, another test used in the evaluation of physical performance is the 2-minute step test. This test, which was developed in 1999, does not require much equipment and space, so the test can be easily applied in any environment. In this test, a height specific to each individual is determined (as high from the ground as the distance between the Spina iliaca anterior superior and the midpoint of the patella), and the participant is asked to raise and lower both knees, respectively, to this height for 2 minutes. These tests used in the evaluation of patients should be valid, reliable and sensitive. In clinical studies, reliability is an important psychometric property. Because stable data are necessary to provide accurate data on treatment effects or the amount of change observed over time. Another important psychometric property is validity. Validity is defined as the degree to which a concept is accurately measured in a quantitative study. Reliability studies of the 2-minute step test in active and sedentary lean adults have been conducted, but the psychometric evaluations necessary for its routine use in patients with TDP have not been performed.